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MetabolomicsAntiviral metabolite 3'-Deoxy-3',4'-didehydro-cytidine is detectable in serum and identifies acute viral infections including COVID-19

BACKGROUND: There is a critical need for rapid viral infection diagnostics to enable prompt case identification in pandemic settings and support targeted antimicrobial prescribing.

METHODS: Using untargeted high-resolution liquid chromatography coupled with...

2022-02-10 | MTBLS718 | MetaboLights
UnknownFactors associated with D-dimer levels in HIV-infected individuals.
Not available
S-EPMC3953205 | biostudies-literature
MetabolomicsNQO1 protects obese mice through improvements in glucose and lipid metabolism.
Chronic nutrient excess leads to metabolic disorders and insulin resistance. Activation of stress-responsive pathways via Nrf2 activation contributes to energy metabolism regulation. Here, inducible activation of Nrf2 in mice and transgenesis of the Nrf2 target, NQO1, conferred protection from diet-...
2024-05-23 | MTBLS2085 | MetaboLights
UnknownDirect structural insight into the substrate-shuttling mechanism of yeast fatty acid synthase by electron cryomicroscopy.
Not available
S-EPMC2889056 | biostudies-literature
MetabolomicsRare and common genetic determinants of metabolic individuality and their effects on human health (INTERVAL study assays)

Garrod’s concept of “chemical individuality” has contributed to comprehension of the molecular origins of human diseases. Untargeted high-throughput metabolomic technologies provide an in-depth snapshot of human metabolism at scale. We studied the genetic architecture of the human plasma metabolo...

2022-09-09 | MTBLS834 | MetaboLights
UnknownA novel derivative of the natural agent deguelin for cancer chemoprevention and therapy.
Not available
S-EPMC2738643 | biostudies-literature
UnknownGlycosylation is an Androgen-Regulated Process Essential for Prostate Cancer Cell Viability.
Not available
S-EPMC4919605 | biostudies-literature
UnknownCryo-EM structure of fatty acid synthase (FAS) from Rhodosporidium toruloides provides insights into the evolutionary development of fungal FAS.
Not available
S-EPMC4456111 | biostudies-literature
ProteomicsRotary substates of mitochondrial ATP synthase reveal the basis of flexible F1-FO coupling
F1FO-ATP synthases play a central role in cellular metabolism, making the energy of the protonmotive force across a membrane available for a large number of energy-consuming processes. We determined the single-particle cryo-EM structure of active dimeric ATP synthase from mitochondria of Polytomella...
ORGANISM(S): Polytomella parva 
2019-05-01 | PXD013530 | Pride
Proteomics Atp synthase Electron microscopy Polytomella 
UnknownSocioeconomic Deprivation: An Important, Largely Unrecognized Risk Factor in Primary Prevention of Cardiovascular Disease.
Not available
S-EPMC9287096 | biostudies-literature
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