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TranscriptomicsRNA-Seq of human K-562 leukaemia cell line with and without K700E mutation in coding region of SF3B1 gene
The aim of this experiment was to compare the transcriptomes of SF3B1 mutant and wildtype isogenic cells at the whole cell, nuclear and cytoplasmic levels. Mutations in SF3B1 are often found in the malignant cells of patients suffering from myelodysplastic syndromes and more rarely in other cancer t...
ORGANISM(S): Homo sapiens 
2019-02-25 | E-MTAB-7192 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of F344/N rats administered with potassium bromate in the drinking water
Ozone has been proposed for water disinfection because it is more efficient than chlorine for killing microbes and results in much lower levels of carcinogenic trihalomethanes than does chlorination. Ozone leads to formation of hypobromous acid in surface waters with high bromine content and forms b...
ORGANISM(S): Rattus norvegicus 
2006-11-14 | E-TOXM-21 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of Bifidobacterium bifidum SC555 in response to various substrates
The purpose of this project was to determine the whole transcriptome response of Bifidobacterium bifidum SC555 to pooled and individual human milk oligosaccharides (HMO) relative to lactose Bacterial isolates grown on lactose, pooled human milk oligosaccharides (HMO), lacto-N-tetraose (LNT), lacto-N...
ORGANISM(S): Bifidobacterium bifidum 
2015-10-28 | E-GEOD-59053 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of Bifidobacterium longum subsp. infantis in response to various substrates
The purpose of this project was to determine the whole transcriptome response of Bifidobacterium longum subsp. Infantis to pooled and individual human milk oligosaccharides (HMO) relative to lactose Bacterial isolates grown on lactose, pooled human milk oligosaccharides (HMO), lacto-N-tetraose (LNT)...
ORGANISM(S): Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088 
2015-10-28 | E-GEOD-58773 | biostudies-arrayexpress
TranscriptomicsHepatic transcription profile study on European eels (Anguilla anguilla) exposed to Hg and b-sitosterol
Many enigmas surround different aspects of freshwater eel biology and life cycle. In the same way different hypothesis about why eels are disappearing from European continental waters have been proposed. One such proposal defends that poor fat accumulation of eels, due to pollution in continental wa...
ORGANISM(S): Anguilla anguilla 
2016-07-31 | E-GEOD-53344 | biostudies-arrayexpress
TranscriptomicsHistone H3.3 and its proteolytically processed form drive a cellular senescence program
In this study, we have uncovered novel proteolytic processing of the histone H3 tail in senescence models in primary fibroblasts and melanocytes. Cleavage of H3 tail occurs at two distinct residues and is mediated by Cathepsin L. We show that variant H3.3 is preferentially cleaved, and that cleaved ...
ORGANISM(S): Homo sapiens 
2014-10-01 | E-GEOD-55949 | biostudies-arrayexpress
TranscriptomicsSlug-dependent upregulation of L1CAM is responsible for the increased invasion potential of pancreatic cancer cells following long-term 5-FU-treatment
In pancreatic cancer the survival rate is low, as the available treatment options usually only extend survival and seldom produce a cure. Drug resistance and disease reoccurrence is the typical reason for death after cancer diagnosis. 5-Fluorouracil (5-FU) is the main chemostatic used in first line ...
ORGANISM(S): Homo sapiens 
2015-08-11 | E-GEOD-58386 | biostudies-arrayexpress
MetabolomicsNQO1 protects obese mice through improvements in glucose and lipid metabolism.
Chronic nutrient excess leads to metabolic disorders and insulin resistance. Activation of stress-responsive pathways via Nrf2 activation contributes to energy metabolism regulation. Here, inducible activation of Nrf2 in mice and transgenesis of the Nrf2 target, NQO1, conferred protection from diet-...
2024-05-23 | MTBLS2085 | MetaboLights
UnknownIdentification of Variant-Specific Functions of PIK3CA by Rapid Phenotyping of Rare Mutations.
Not available
S-EPMC4681596 | biostudies-literature
UnknownEngineering and Functional Characterization of Fusion Genes Identifies Novel Oncogenic Drivers of Cancer.
Not available
S-EPMC5568774 | biostudies-literature
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