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TranscriptomicsVisualization of cancer initiating cell in the vascular niche utilized with transcriptional activity of PSF1
Identification of cancer stem/initiating cells (CSCs/CICs) by a specific marker is useful for diagnosis and therapy of cancer. We have determined that PSF1 which plays a role in DNA replication in lower species is strongly expressed in wide range of normal stem cell population. Here, utilizing the t...
ORGANISM(S): Mus musculus 
2010-04-12 | E-GEOD-17112 | biostudies-arrayexpress
UnknownPrediction of the Sex-Associated Genomic Region in Tunas (Thunnus Fishes).
Not available
S-EPMC8693018 | biostudies-literature
TranscriptomicsIL-4 mediated gene expression profiles in vascular endothelial cells
Endothelial cell activation and dysfunction underlie many vascular disorders, including atherosclerosis and inflammation. Here, we show that interleukin (IL)-4 markedly induced vascular cell adhesion molecule (VCAM)-1, both in cultured endothelial cells and in the intact endothelium in mice. Combine...
ORGANISM(S): Homo sapiens 
2011-05-01 | E-GEOD-28117 | biostudies-arrayexpress
TranscriptomicsExpression data during vascular endothelial cells differentiation from mouse embryonic stem cells
Although differentiation of mice embryonic stem cells into vascular endothelial cells (ECs) gives a model for investigating molecular mechanisms of vascular development in vivo, temporal dynamics of gene expressions and chromatin modifications have not been studied until now. Here, we interrogated t...
ORGANISM(S): Mus musculus 
2016-07-18 | E-GEOD-76964 | biostudies-arrayexpress
TranscriptomicsThe Calcineurin-NFAT-Angiopoietin 2 signaling axis in lung endothelium is critical for the establishment of lung metastases
The pre-metastatic niche is a pre-determined site of metastases, awaiting the influx of tumor cells. Here we demonstrate that the calcineurin-NFAT pathway is activated specifically in lung endothelium prior to the detection of tumor cells that preferentially metastasize to the lung. We previously sh...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-GEOD-48841 | biostudies-arrayexpress
TranscriptomicsDevelopment of gene expression signatures for ANP in HUVEC
Analysis of HUVEC treated with ANP. ANP is a cardiac hormone, binding to the guanylate cyclase-A (GC-A) receptor with a major role in cardiovascular homeostatic mechanisms. Results provide insight into the molecular mechanisms of ANP in vascular endothelial cell. ANP induced gene expression in HUVEC...
ORGANISM(S): Homo sapiens 
2014-04-23 | E-GEOD-56976 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis shoots and roots in response to exogenous H2O2 with differential kinetics
Arabidopsis plants (Col-0) were hydroponically grown for 10 days at 22°C under 30~40 μE·m−2·s−1 and continuous light conditions. Treatment with 100 mM H2O2 or sterile distilled water as mock control by spraying for shoot treatments, or dipping for root treatments. Relationship between treated and ha...
ORGANISM(S): Arabidopsis thaliana 
2019-06-01 | E-MTAB-4961 | biostudies-arrayexpress
TranscriptomicsGATA2 in human vascular endothelial cells
GATA2 is well recognized as a key transcription factor and regulator of cell type specificity and differentiation. Here, we carried out comparative chromatin immunoprecipitation with comprehensive sequencing (ChIP-seq) to determine genome-wide occupancy of GATA2 in endothelial cells and erythroids, ...
ORGANISM(S): Homo sapiens 
2011-06-13 | E-GEOD-28304 | biostudies-arrayexpress
GenomicsGlobal analysis of NFATc1 binding and histone marks in VEGF-activated endothelial cells
We performed the newly mapping of genome-wide NFATc1 binding events in VEGF-stimulated primary cultured endothelial cells, by chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq). Combined NFATc1 ChIP-seq profile and the epigenetic histone marks revealed that predominant N...
ORGANISM(S): Homo sapiens 
2013-09-01 | E-GEOD-49428 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of tolerizing murine cardiac allograft to understand the precise mechanisms of immunological tolerance.
C57/BL6 to C57/BL6; Balb/c to C57/BL6; Balb/c to C57/BL6 with anti CD80/86 mAb; Identificaton of gene expression profile in tolerizing murine cardiac allograft by co-stimulatory blockade. The induction of specific tolerance would be the ultimate achievement in transplant immunology, but the precise ...
ORGANISM(S): Mus musculus 
2007-12-15 | E-GEOD-582 | biostudies-arrayexpress
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