Minichromosome maintenance protein-2

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1. Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark; 2. Proteomics and Singal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany (1)
Research Institute of Molecular Pathology (IMP), Campus-Vienna-Biocenter-1, Vienna Biocenter, 1030 Vienna, Austria (1)
Institute of Molecular and Cellular Biology, National Taiwan University (1)
Metabolomics and Proteomics Core, Helmholtz zentrum Muenchen (1)
1Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA 2Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA 5Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA 8Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA (1)
Schuler Assistant Professor In Translational Organic Chemistry, School of Chemistry, Trinity College Dublin, Republic of Ireland (1)
Institute of Molecular & Cellular Biology, National Taiwan University, Taiwan (1)
Anatomy and Cell Biology, University of Sherbrooke, Canada (1)
Molecular Proteomics Laboratory (MPL) Biologisch-Medizinisches Forschungszentrum (BMFZ) Heinrich-Heine-Universität Düsseldorf (1)
Department of Anatomy and Cell Biology, Faculty of Medecine and Health Sciences, Université de Sherbrooke (1)
Department of Plant Biosience, Pusan National University, Miryang 50463, Republic of Korea (1)
TU Wien, Institute of Chemical Technologies and Analytics, 1060 Wien, Austria (1)
Institute of Molecular and Cellular Biology, National Taiwan University, Taipei, Taiwan. Department of Life Science, National Taiwan University, Taipei, Taiwan. Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan (1)
Department of Cell Biology, Microbiology and Molecular Biology University of South Florida Tampa, Florida (1)
Histone Modifications Group Zentrallabor für Proteinanalytik BioMedical Center Faculty of Medicine Ludwig-Maximilians-University of Munich Germany (1)

Tags

xref:PubMed:36765030 (2)
xref:PubMed:36778110 (1)
xref:PubMed:40399407 (1)

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Quantitative phosphoproteomics analysis uncovers the regulatory networks of minichromosome maintenance protein 2 in lung cancer cells

Minichromosome maintenance protein 2 (MCM2) is a licensing factor for DNA replication. It interacts with other MCM proteins to comprise MCM2-7 complex, which acts as a helicase for DNA unwinding and limits DNA replication to one round per cell cycle. MCM2 has been widely used as a biomarker for prol...

ORGANISM(S): Homo sapiens (Human)

2018-10-24 | PXD002736 | Pride

Proteome of silenced minichromosome maintenance protein 2 with siRNA on non-small cell lung cancer H1299 cells

Lung cancer is the leading cause of cancer-related mortality. The two main lung cancer types are small cell lung cancer (SCLC) and non-SCLC (NSCLC), where NSCLC comprises about 80-85% of all lung cancer. Despite the introduction of improved treatments, the overall survival rate of lung cancer patien...

ORGANISM(S): Homo sapiens (Human)

2018-10-26 | PXD003743 | Pride

Non small cell lung cancer h1299 cells Rna interference Proteome Minichromosome maintenance protein 2 Itraq Lc-ms/ms

Diagnosis of bladder cancer by immunocytochemical detection of minichromosome maintenance protein-2 in cells retrieved from urine.

Not available

S-EPMC3494445 | biostudies-literature

Comprehensive characterization of Minichromosome Maintenance Complex (MCM) protein interactions using affinity and proximity purifications coupled to mass spectrometry.

This project is the complete interactome of the Minichromosome Maintenance (MCM) complex by using AP-MS and BioID approaches for all the different MCM proteins. Overall, our analysis identified unique and shared interaction partners and proteins enriched for distinct biological processes including D...

ORGANISM(S): Homo sapiens (Human)

2016-08-09 | PXD004089 | Pride

Ap-ms Bioid Mcm complex

Novel protein contact points among TP53 and minichromosome maintenance complex proteins 2, 3, and 5.

Not available

S-EPMC9761056 | biostudies-literature

Unwinding 20 Years of the Archaeal Minichromosome Maintenance Helicase.

Not available

S-EPMC7043673 | biostudies-literature

Effect of minichromosome maintenance protein 2 deficiency on the locations of DNA replication origins.

Not available

S-EPMC4381527 | biostudies-literature