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MiR34 exhibits consistent downregulation during SMA progression in both human and rodent contexts. Mir34 family-knockout mice display axon swelling and reduced neuromuscular junction (NMJ) end-plates, recapitulating SMA pathology. MiR34 family may target synapse formation and several core pathways t...
ORGANISM(S): Mus musculus 
2023-09-21 | GSE228244 | GEO
MiR34 Contributes to Spinal Muscular Atrophy and AAV9-mediated Delivery of MiR34a Ameliorates the Motor Deficits in SMA Mice
Svetoslav Nikolov, Olaf Wolkenhauer, Julio Vera & Momchil Nenov. The role of cooperativity in a p53-miR34 dynamical mathematical model. Journal of Theoretical Biology 495 (2020). The objective of this study is to evaluate the role of cooperativity, captured by the Hill coefficient, in a minimal mat...
2024-09-02 | BIOMD0000001057 | BioModels
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ORGANISM(S): Homo sapiens 
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