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TranscriptomicsRNA-seq of hepatocytes obtained through step-wise differentiation of hIPSCs from a patient with A1AT deficiency and its point mutation-corrected isogenic hIPSC line. Comparison to primary hepatocytes from a healthy donor and an A1AT-deficient patient.
A1AT deficiency is an autosomal not recessive disorder caused by mutations in the SERPINA1 gene. Individuals with the Z variant retain polymerised protein in the endoplasmic reticulum of hepatocytes, predisposing them to liver disease. This study primarily aimed to uncover the molecular mechanisms t...
ORGANISM(S): Homo sapiens 
2018-06-26 | E-MTAB-6781 | biostudies-arrayexpress
TranscriptomicsSuppression of breast tumor growth and metastasis by an engineered transcription factor
Abstract Maspin is a tumor and metastasis suppressor playing an essential role as gatekeeper of tumor progression. It is highly expressed in epithelial cells but is silenced in the onset of metastatic disease by epigenetic mechanisms. Reprogramming of Maspin epigenetic silencing offers a therapeutic...
ORGANISM(S): Homo sapiens 
2011-08-22 | E-GEOD-27842 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human biopsies from subcutaneous adipose tissue from unrelated individuals reveals galanin preproprotein is associated with elevated plasma triglycerides
Assessment of mRNA expression levels in fat biopsies from subcutaneous adipose tissue from unrelated individuals. Experiment Overall Design: Subcutaneous adipose tissue from 49 unrelated individuals.
ORGANISM(S): Homo sapiens 
2009-01-17 | E-GEOD-13506 | biostudies-arrayexpress
TranscriptomicsmicroRNA profiling of multiple myeloma bone marrow
Bone marrow microenvironment in MM contains a unique miR signature, which is partially present and detectable in the peripheral blood. A subset of miRs (let-7i, miR-106b, miR-15a, and miR16) shows aberrant expression in the precursor lesion of MGUS, while aberrant expression of other miRs (let-7a, m...
ORGANISM(S): Homo sapiens 
2016-07-01 | E-GEOD-49261 | biostudies-arrayexpress
UnknownInfluenza epidemiology and influenza vaccine effectiveness during the 2016-2017 season in the Global Influenza Hospital Surveillance Network (GIHSN).
Not available
S-EPMC6498567 | biostudies-literature
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