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TranscriptomicsImplications of high level pseudogene transcription in Mycobacterium leprae
Approximately half of M. lepraeâ??s transcriptome consists of inactive gene products. This has an impact on overall energy and resource consumption without potential benefit to this organism. However, multiple translational â??silencingâ?? mechanisms are present, reducing additional energy and resou...
ORGANISM(S): Mycobacterium leprae 
2010-06-24 | E-GEOD-17191 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of 38 Bartonella henselae isolates from natural feline populations and clinical strains to investigate genomic diversity and the effect of growth time
The genomic diversity of 38 Bartonella henselae isolates was studied by comparative genomic hybridizations. In addition, the effect of growth time (5 or 10 days) was studied for 5 strains.
ORGANISM(S): Bartonella henselae 
2006-08-29 | E-TABM-88 | biostudies-arrayexpress
TranscriptomicsWildtype, miR-1-1 KO, miR-1 Double het P2 mixed strain heart analysis (MoGene 2.0 ST Arrays).
Neonatal hearts (P2) from wildtype, miR-1-1 null and miR-1-2 +/-: miR-1-1 +/- double heterozygote animals were isolated and total RNA was extracted with TRIzol (Invitrogen), following the manufacturer’s suggested protocol. Genomic DNA was removed using a gDNA eliminator column (Qiagen).  Samples wer...
ORGANISM(S): Mus musculus 
2013-10-19 | E-GEOD-51394 | biostudies-arrayexpress
UnknownA conserved archaeal protein with evolutionary links to bacterial ribosome hibernation and eukaryotic energy sensing
Not available
S-SCDT-10_1038-S44318-026-00918-6 | biostudies-other
TranscriptomicsDual Mechanisms by which MiR-125b Represses IRF4 to Induce Myeloid and B cell Leukemias
The oncomir microRNA-125b (miR-125b) is up-regulated in a variety of human neoplastic blood disorders and constitutive up-regulation of miR-125b in mice can promote myeloid and B cell leukemia. We found that miR-125b promotes myeloid and B cell neoplasm by inducing tumorigenesis in hematopoietic pro...
ORGANISM(S): Mus musculus 
2014-06-27 | E-GEOD-58900 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human breast cancer cell line profiles
mRNA breast cancer cell lines were profiled to study the function of hsa-mir-221 and hsa-mir-222. MCF7 cell lines were profiled after treatment with mir-221/222 mimics, and compared to profiles with transfection controls. Similarly, MDA-MB-231 cell lines were profiled after treatment with mir-221/22...
ORGANISM(S): Homo sapiens 
2009-01-13 | E-GEOD-10890 | biostudies-arrayexpress
TranscriptomicsGene expression Classification of Colon Cancer defines six molecular subtypes with distinct clinical, molecular and survival characteristics [CGH]
From a clinical and molecular perspective, colon cancer (CC) is a heterogeneous disease but to date no classification based on high-density transcriptome data has been established. The aim of this study was to build up a robust molecular classification of mRNA expression profiles (Affymetrix U133Pl...
ORGANISM(S): Homo sapiens 
2013-05-22 | E-GEOD-40966 | biostudies-arrayexpress
TranscriptomicsGene expression Classification of Colon Cancer defines six molecular subtypes with distinct clinical, molecular and survival characteristics [Expression]
From a clinical and molecular perspective, colon cancer (CC) is a heterogeneous disease but to date no classification based on high-density transcriptome data has been established. The aim of this study was to build up a robust molecular classification of mRNA expression profiles (Affymetrix U133Pl...
ORGANISM(S): Homo sapiens 
2013-05-22 | E-GEOD-39582 | biostudies-arrayexpress
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