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UnknownCross-Sectional Comparison of Sleep-Disordered Breathing in Native Peruvian Highlanders and Lowlanders.
Not available
S-EPMC5361758 | biostudies-literature
UnknownIncreased Cardiometabolic Risk and Worsening Hypoxemia at High Altitude.
Not available
S-EPMC4913510 | biostudies-literature
TranscriptomicsRIP: miR-202 mimic-transfected HeLa cells vs. negative control
Potential miR-202 targets were identified using a targetome-wide RIP-based microarray. HeLa cells were transfected with either a miR-202 mimic or a scrambled single-stranded RNA negative control. RNA was isolated from total cell lysate prior to IP and from antibody-immobilized Protein G agarose be...
ORGANISM(S): Homo sapiens 
2012-12-19 | E-GEOD-42981 | biostudies-arrayexpress
TranscriptomicsAge-related changes in microRNA levels in serum (mRNA)
Age-related changes in microRNA levels in serum 20 nM biotinylated miRIDIAN miR-1248 mimic (Thermo Scientific) or a negative control, biotinylated miRIDIAN C. elegans miR-67 (here named Con-miR) using Lipofectamine 2000. Forty eight hours post transfection, total RNA was isolated using the mirVana...
ORGANISM(S): Homo sapiens 
2013-10-09 | E-GEOD-51309 | biostudies-arrayexpress
TranscriptomicsPersistence of seed-based activity following microRNA segmentation
microRNAs are M-bM-^HM-<22 nucleotide regulatory RNAs that are processed into duplexes from hairpin structures and incorporated into Argonaute proteins. We find that a nick in the middle of the guide strand of an miRNA sequence allows for seed-based targeting characteristic of miRNA activity. Insert...
ORGANISM(S): Homo sapiens 
2010-11-12 | E-GEOD-25224 | biostudies-arrayexpress
TranscriptomicsEffect of miR-144 and miR-451 expression on lung epithelial cell responses to influenza infection at 1 and 18 hours.
Antiviral responses must be regulated to rapidly defend against infection while minimizing inflammatory damage, but the mechanisms for establishing the magnitude of response within an infected cell are not well understood. miRNAs are small non-coding RNAs that negatively regulate protein levels by b...
ORGANISM(S): Mus musculus 
2013-09-11 | E-GEOD-50742 | biostudies-arrayexpress
TranscriptomicsAge-related changes in microRNA levels in serum
microRNAs (miRNAs) are small noncoding RNAs that post-transcriptionally regulate gene expression by targeting specific mRNAs. Altered expression of circulating miRNAs have been associated with age-related diseases including cancer and cardiovascular disease. Although we and others have found an age-...
ORGANISM(S): Homo sapiens 
2013-12-18 | E-GEOD-53439 | biostudies-arrayexpress
TranscriptomicsAn integrated genomic and expression analysis of 7q deletion in SMZL (Illumina Infinium Human Methylation 27 array)
Splenic marginal zone lymphoma (SMZL) is an indolent B-cell lymphoproliferative disorder characterised by 7q32 deletion, but the target genes of this deletion remain unknown. In order to elucidate the genetic target of this deletion, we performed an integrative analysis of the genetic, epigenetic, t...
ORGANISM(S): Homo sapiens 
2012-08-30 | E-GEOD-35424 | biostudies-arrayexpress
TranscriptomicsHigh-throughput sequencing of small RNA transcriptomes and DNA microarrays reveal critical biological features targeted by microRNAs in cell models used for squamous cell cancer research
Background The implication of post-transcriptional regulation by microRNAs in molecular mechanisms underlying cancer disease is well documented. However, their interference at the cellular level is not fully explored. Functional in vitro studies are fundamental for the comprehension of their role; n...
ORGANISM(S): Homo sapiens 
2013-12-30 | E-GEOD-41436 | biostudies-arrayexpress
TranscriptomicsMicroarray of IVM susceptable and resistant Haemonchus contortous
Anthelmintic resistance is a major problem in the global fight against parasitic nematodes., Most previous studies have focused on the analysis of potential candidate genes that may have a role in resistance. Here we take a novel approach in the important parasite, Haemonchus contortus, by investiga...
ORGANISM(S): Haemonchus contortus 
2016-03-25 | E-GEOD-79542 | biostudies-arrayexpress
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