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ProteomicsGlycoAvatars: Bead-Coated Membrane Models for Studying the Cancer-Immune Cells Interactome
Immature O-glycosylation, characterized by the Tn antigen expression rather than complex glycans, is prevalent in advanced solid tumors and promotes immune evasion. We developed GlycoAvatars, magnetic beads coated with plasma-membrane glycoproteins from glycoengineered cancer cell models, to identif...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD060750 | Pride
TranscriptomicsDeep sequencing of human naive CD4 T cells identifies miR-34c-5p as a novel regulator of T cell activation and HIV replication
We generated a model for miR-34c-5p overexpression by transfecting Jurkat T cell line with a pcDNA3 vector containing the pre-miR-34c-5p precursor sequence and selecting for antibiotic resistance to isolate both pools and clones of stably transfected cells (J34c cells), in parallel with control cell...
ORGANISM(S): Homo sapiens 
2016-12-21 | E-MTAB-4190 | biostudies-arrayexpress
TranscriptomicsDeep sequencing of human naive CD4 T cells identifies miR-34c-5p as a novel regulator of T cell activation and HIV replication
Cell activation is a vital step for T cell memory/effector differentiation as well as for productive HIV infection. To identify novel regulators of this process, we used next generation sequencing to profile changes in microRNA expression occurring in purified human naive CD4 T cells in response to ...
ORGANISM(S): Homo sapiens 
2016-12-21 | E-MTAB-4214 | biostudies-arrayexpress
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