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TranscriptomicsThe HDAC inhibitor panobinostat (LBH589) inhibits Acute Lymphoblastic leukemia (ALL) in vitro and in vivo in a new characterized human ALL mice model (TOM-1 and MOLT-4)
Histone deacetylases (HDACs) have been identified as therapeutic targets due to regulatory function in DNA structure and organization. We have analyzed the role of the LBH589, a novel pan inhibitor of class I and II HDACs, in Acute Lymphoblastic Leukemia. In vitro, LBH589 was shown to induce a dose...
ORGANISM(S): Homo sapiens 
2012-04-17 | E-GEOD-26790 | biostudies-arrayexpress
TranscriptomicsThe HDAC inhibitor panobinostat (LBH589) inhibits Acute Lymphoblastic leukemia (ALL) in vitro and in vivo in a new characterized human ALL mice model (SNP)
Histone deacetylases (HDACs) have been identified as therapeutic targets due to regulatory function in DNA structure and organization. We have analyzed the role of the LBH589, a novel pan inhibitor of class I and II HDACs, in Acute Lymphoblastic Leukemia. In vitro, LBH589 was shown to induce a dose...
ORGANISM(S): Homo sapiens 
2012-04-17 | E-GEOD-26792 | biostudies-arrayexpress
TranscriptomicsThe HDAC inhibitor panobinostat (LBH589) inhibits Acute Lymphoblastic leukemia (ALL) in vitro and in vivo in a new characterized human ALL mice model (Illumina)
Histone deacetylases (HDACs) have been identified as therapeutic targets due to regulatory function in DNA structure and organization. We have analyzed the role of the LBH589, a novel pan inhibitor of class I and II HDACs, in Acute Lymphoblastic Leukemia. In vitro, LBH589 was shown to induce a dose...
ORGANISM(S): Homo sapiens 
2012-04-17 | E-GEOD-26791 | biostudies-arrayexpress
TranscriptomicsThe HDAC inhibitor panobinostat (LBH589) inhibits Acute Lymphoblastic leukemia (ALL) in vitro and in vivo in a new characterized human ALL mice model (ALL-B and ALL-T)
Histone deacetylases (HDACs) have been identified as therapeutic targets due to regulatory function in DNA structure and organization. We have analyzed the role of the LBH589, a novel pan inhibitor of class I and II HDACs, in Acute Lymphoblastic Leukemia. In vitro, LBH589 was shown to induce a dose...
ORGANISM(S): Homo sapiens 
2012-04-17 | E-GEOD-26789 | biostudies-arrayexpress
ProteomicsModelling Premature Cardiac Aging with Induced Pluripotent Stem Cells From a Hutchinson-Gilford Progeria Syndrome Patient
Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare genetic disorder that causes accelerated aging and a high risk of cardiovascular complications. However, the underlying mechanisms of cardiac complications of this syndrome are not fully understood. This study modeled HGPS using cardiomyocytes (C...
ORGANISM(S): Homo sapiens (Human) 
2022-11-10 | PXD036557 | Pride
Progeria Proteomics Ips 
UnknownUse of glucocorticoids megadoses in SARS-CoV-2 infection in a spanish registry: SEMI-COVID-19.
Not available
S-EPMC8782507 | biostudies-literature
UnknownModelling premature cardiac aging with induced pluripotent stem cells from a hutchinson-gilford Progeria Syndrome patient.
Not available
S-EPMC9726722 | biostudies-literature
UnknownTRP14 is the rate-limiting enzyme for intracellular cystine reduction and regulates proteome cysteinylation.
Not available
S-EPMC11217419 | biostudies-literature
TranscriptomicsTranscription profiling of mouse wild type or mir-155 deficient B cells after stimulation with LPS and IL4
Wild type or miR-155 deficient b cells from 5 individuals each were stimulated with LPS and IL4 for 24hs and profiled.
ORGANISM(S): Mus musculus 
2007-11-21 | E-MEXP-1325 | biostudies-arrayexpress
UnknownDownregulation of thioredoxin-1-dependent CD95 S-nitrosation by Sorafenib reduces liver cancer.
Not available
S-EPMC7210585 | biostudies-literature
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