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TranscriptomicsmicroRNA signatures of iPSCs and endoderm-derived tissues
MicroRNAs (miRNAs), small non-coding RNAs that fine-tune gene expression, play multiple roles in the cell, including cell fate specification. We have analyzed the differential expression of miRNAs during fibroblast reprogramming into induced pluripotent stem cells (iPSCs) and endoderm induction in i...
ORGANISM(S): Mus musculus 
2015-02-20 | E-GEOD-36046 | biostudies-arrayexpress
TranscriptomicsThe HER2-encoded miR-4728-3p regulates ESR1 through a non-canonical internal seed interaction
Since the early 1980s remarkable progress has been made in understanding the role of the HER2 locus in carcinogenesis, but many details of its regulatory network are still elusive. We recently reported the finding of 367 new human microRNA (miRNA) genes of which one, mir-4728, is encoded in an intro...
ORGANISM(S): Homo sapiens 
2014-08-13 | E-GEOD-55822 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human ASCs expanded with 10% FBS and in FBS-deprived condition
In this experiment we determined the effects of FBS supplementation and subsequent deprivation (after second passage) on the whole transcriptome, including comprehensive mRNA and miRNA profiling.
ORGANISM(S): Homo sapiens 
2018-08-09 | E-MTAB-6436 | biostudies-arrayexpress
TranscriptomicsMicroRNAs differentially present in the plasma of HIV elite controllers
Elite controllers maintain HIV-1 viral loads below the limit of detection. The mechanisms responsible for this phenomenon are poorly understood. As microRNAs (miRNAs) are regulators of gene expression and some of them modulate HIV infection, we have studied the miRNA profile in plasma from HIV elite...
ORGANISM(S): Homo sapiens 
2014-08-04 | E-GEOD-58868 | biostudies-arrayexpress
TranscriptomicsNF-κB-direct activation of microRNAs with repressive effects on monocyte-specific genes is critical for osteoclast differentiation
In this study, analysis of miRNA expression changes in osteoclast differentiation from human primary monocytes revealed the rapid upregulation of two miRNA clusters, miR-212/132 and miR-99b/let-7e/125a. We demonstrate that they negatively target monocyte-specific and immunomodulatory genes like TNFA...
ORGANISM(S): Homo sapiens 
2014-12-03 | E-GEOD-63773 | biostudies-arrayexpress
TranscriptomicsHigh-throughput sequencing of small RNA transcriptomes and DNA microarrays reveal critical biological features targeted by microRNAs in cell models used for squamous cell cancer research
Background The implication of post-transcriptional regulation by microRNAs in molecular mechanisms underlying cancer disease is well documented. However, their interference at the cellular level is not fully explored. Functional in vitro studies are fundamental for the comprehension of their role; n...
ORGANISM(S): Homo sapiens 
2013-12-30 | E-GEOD-41436 | biostudies-arrayexpress
UnknownImpact of clinical phenotypes on management and outcomes in European atrial fibrillation patients: a report from the ESC-EHRA EURObservational Research Programme in AF (EORP-AF) General Long-Term Registry.
Not available
S-EPMC8527730 | biostudies-literature
UnknownImpact of renal impairment on atrial fibrillation: ESC-EHRA EORP-AF Long-Term General Registry.
Not available
S-EPMC9287022 | biostudies-literature
UnknownClinical complexity and impact of the ABC (Atrial fibrillation Better Care) pathway in patients with atrial fibrillation: a report from the ESC-EHRA EURObservational Research Programme in AF General Long-Term Registry.
Not available
S-EPMC9440492 | biostudies-literature
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