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TranscriptomicsUnique MicroRNA Expression Signature Predicts Survival, Metastases and Recurrence of HCC
In this study we investigated the miRNA expression profile of Hepatocellular carcinoma (HCC) specimens from radical resection. We developed a unique 20 miRNA signature that could significantly distinguish HCC venous metastasis from metastasis-free HCC. In contrast to HCC staging systems, this signat...
ORGANISM(S): Homo sapiens 
2008-01-14 | E-GEOD-6857 | biostudies-arrayexpress
TranscriptomicsMiRNA Expression Profile Study Reveals a Prognostic Signature for Esophageal Squamous Cell Carcinoma
Esophageal cancer is a highly malignant and prevalent cancer worldwide. Current TNM staging system is insufficient for prognosis of esophagus squamous cell carcinoma (ESCC) patients. The aim of this study is to evaluate miRNA expression profile of ESCC and identify a miRNA signature which robustly p...
ORGANISM(S): Homo sapiens 
2014-08-01 | E-GEOD-43732 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profiling of male breast cancer
To test the hypothesis that there is a specific miRNA expression signature which characterizes male breast cancers, we performed miRNA microarray analysis in a series of male breast cancers and compared them to cases of male gynecomastia and female breast cancers miRNA microarray analysis was perfor...
ORGANISM(S): Homo sapiens 
2010-05-16 | E-GEOD-17155 | biostudies-arrayexpress
TranscriptomicsELAVL1 modulates transcriptome-wide miRNA binding in murine macrophages
Post-transcriptional gene regulation by miRNAs and RNA binding proteins (RBP) is important in development, physiology and disease. To examine the interplay between miRNAs and the RBP ELAVL1 (a.k.a. HuR), we mapped miRNA binding sites on a transcriptome-wide scale in WT and Elavl1 knockout murine bon...
ORGANISM(S): Mus musculus 
2015-04-23 | E-GEOD-63199 | biostudies-arrayexpress
TranscriptomicsGastric cancer: cancer vs. normal, chemoresistance signature that correlates with time to progression of disease
microRNA profiling of gastric cancer vs. normal, pre-/-post CF (cisplatin/fluorouracil) chemotherapy. Biopsy samples were collected prior to chemotherapy from 90 gastric cancer patients treated with CF and from 34 healthy volunteers. At the time of disease progression, post-treatment samples were c...
ORGANISM(S): Homo sapiens 
2011-12-16 | E-GEOD-30070 | biostudies-arrayexpress
GenomicsMiRNA SIGNATURE FOR ORAL SQUAMOUS CELL CARCINOMA
MiRNA SIGNATURE FOR ORAL SQUAMOUS CELL CARCINOMA
PRJNA706589 | ENA
TranscriptomicsAnalysis of miRNA profiles in CD4+ T-lymphocytes following exposure to HIV-1
Assessment of the extent to which the altered profiles of miRNA expression influence viral replication and latency, as well as the efficiency of host defenses, may be useful for understanding the basis of the HIV-1-related alterations in cellular physiology and immunologic control. To this end, thre...
ORGANISM(S): Homo sapiens 
2011-11-08 | E-GEOD-33514 | biostudies-arrayexpress
TranscriptomicsA specific miRNA signature correlates with complete pathological response to neoadjuvant chemo-radiotherapy in locally advanced rectal cancer
Background: MicroRNAs (miRNAs) are small, non-coding, RNA molecules which regulate numerous cellular processes. Specific miRNA may be abnormally down-regulated or up-regulated in colorectal cancer and have been found associated with prognosis or response to treatments. However, no study has ever ad...
ORGANISM(S): Homo sapiens 
2012-04-24 | E-GEOD-29298 | biostudies-arrayexpress
TranscriptomicsmiRNA profiles of Wilms tumor patients and controls
Blood-borne miRNA signatures have recently been reported for various tumor diseases. Here, we compared the miRNA signature in Wilms tumor patients prior to and after preoperative chemotherapy according to the SIOP protocol 2001. We did not find a significant difference between the miRNA signatures o...
ORGANISM(S): Homo sapiens 
2013-07-22 | E-GEOD-38419 | biostudies-arrayexpress
TranscriptomicsPost-transcriptional generation of miRNA variants by multiple nucleotidyl transferases contributes to miRNA transcriptome complexity (Validation 1)
Modification of microRNA sequences by the 3' addition of nucleotides to generate so-called M-bM-^@M-^\isomiRsM-bM-^@M-^] adds to the complexity of miRNA function, with recent reports showing that 3' modifications can influence miRNA stability and efficiency of target repression. Here we show that th...
ORGANISM(S): synthetic construct 
2011-06-15 | E-GEOD-26916 | biostudies-arrayexpress
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