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TranscriptomicsDevelopmental characterization of the microRNAs-specific C. elegans Argonautes alg-1 and alg-2
This study analyzes miRNA association with ALG-1 and ALG-2 in different stages during larval development of C. elegans Staged animals (L1, L2, L3, L4) - the alg-2 mutant expressing tagged-ALG-2, alg-1 mutant, and wild type controls - were lysed. ALG-1 IP or ALG-2 (GFP) IP was performed using tags f...
ORGANISM(S): Caenorhabditis elegans 
2012-02-03 | E-GEOD-35505 | biostudies-arrayexpress
TranscriptomicsAnalysis of small RNA response to viral infection in C.elegans
Dissection of the small RNA pathway required for generation of an antiviral small RNA response Small non-coding RNA (~15-30nt) was extracted from animals infected with the Orsay virus
ORGANISM(S): Caenorhabditis elegans 
2013-06-01 | E-GEOD-41693 | biostudies-arrayexpress
TranscriptomicsExpression analysis of Caenorhabditis elegans Bristol N2 rsd-2 and rsd-6 single mutants at 25°C and 20°C
Investigation of whole genome gene expression level changes in early generation Caenorhabditis elegans Bristol N2 rsd-2 and Bristol N2 rsd-6 single mutants, compared to late-generation strains at 25°C and 20°C A six chip study using total RNA recovered from two separate alleles of Caenorhabditis e...
ORGANISM(S): Caenorhabditis elegans 
2013-06-01 | E-GEOD-40459 | biostudies-arrayexpress
MetabolomicsA metabolomic strategy defines the regulation of lipid content and global metabolism by Δ9 desaturases in Caenorhabditis elegans
Caenorhabditis elegans provides a genetically tractable model organism to investigate the network of genes involved in fat metabolism and how regulation is perturbed to produce the complex phenotype of obesity. C. elegans possess the full range of desaturases, including the delta-9 desaturases expre...
2012-02-14 | MTBLS3 | MetaboLights
TranscriptomicsCompetition between viral-derived and endogenous small RNA pathways regulates gene expression in response to viral infection in C.elegans.
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Caenorhabditis elegans 
2013-06-01 | E-GEOD-41058 | biostudies-arrayexpress
TranscriptomicsReduced insulin/IGF-1-like signaling restores germ cell immortality in Caenorhabditis elegans Piwi mutants
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Caenorhabditis elegans 
2013-06-01 | E-GEOD-40573 | biostudies-arrayexpress
TranscriptomicsExpression analysis of Caenorhabditis elegans Bristol N2 prg-1 and Bristol N2 prg-1; daf-2 double mutant
Investigation of whole genome gene expression level changes in early generation Caenorhabditis elegans Bristol N2 prg-1 and Bristol N2 prg-1; daf-2 double mutant, compared to late-generation strains. A seven chip study using total RNA recovered from three separate alleles of Caenorhabditis elegans B...
ORGANISM(S): Caenorhabditis elegans 
2013-06-01 | E-GEOD-40569 | biostudies-arrayexpress
TranscriptomicsFunction, targets and evolution of Caenorhabditis elegans piRNAs (small RNA-Seq)
piRNAs are required to maintain germline integrity and fertility but their mechanism of action is poorly understood. Here we demonstrate that C. elegans piRNAs silence transcripts in trans through imperfectly complementary sites. We find that target silencing is independent of Piwi endonuclease acti...
ORGANISM(S): Caenorhabditis elegans 
2012-06-18 | E-GEOD-28617 | biostudies-arrayexpress
TranscriptomicsThe microRNA miR-124 controls gene expression in the sensory nervous system of Caenorhabditis elegans
We generated animals carrying a genomically integrated mir-124 promoter::gfp transgene and identified mir-124 promoter::GFP labelled cells as a subset of the C. elegans sensory neurons. We used fluorescence activated cell sorting (FACS) to isolate four distinct cell populations: mir-124 expressing (...
ORGANISM(S): Caenorhabditis elegans 
2010-03-22 | E-GEOD-16050 | biostudies-arrayexpress
TranscriptomicsTransgenerational profiling of small non-coding RNAs in C.elegans RSD mutants
Attempt to identify progressive changes in small non-coding RNA levels in C.elegans lacking RSD-2 or RSD-6. Small non-coding RNA (18-30nt) was extracted from animals the indicated number of generations after homozygosity was established
ORGANISM(S): Caenorhabditis elegans 
2013-06-01 | E-GEOD-40457 | biostudies-arrayexpress
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