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ProteomicsLENG8 mediates nuclear retention and degradation of misprocessed mRNAs and noncoding RNAs
Incompletely processed and misprocessed mRNAs as well as numerous noncoding RNAs are retained in the nucleus and often degraded, and defects in this quality control mechanism have been linked to various diseases, including cancer and neurodegeneration. However, the underlying mechanisms remain poorl...
ORGANISM(S): Homo sapiens (Human) 
2026-03-30 | PXD065356 | Pride
Misprocessed rnas Rna nuclear retention Rna degradation Leng8 
GenomicsLENG8 Functions as a Quality Control Checkpoint for Nuclear Retention and Degradation of Misprocessed RNAs
LENG8 Functions as a Quality Control Checkpoint for Nuclear Retention and Degradation of Misprocessed RNAs
PRJNA1276448 | ENA
TranscriptomicsLENG8 Functions as a Quality Control Checkpoint for Nuclear Retention and Degradation of Misprocessed RNAs
Quality control is essential for maintaining proper gene expression. For example, aberrantly processed RNAs are retained and degraded in the nucleus, and defects in this process have been linked to various diseases, including cancer and neurodegeneration. However, the underlying mechanisms of RNA nu...
ORGANISM(S): Homo sapiens 
2025-08-18 | GSE299756 | GEO
UnknownRIG-I like receptor sensing of host RNAs facilitates the cell-intrinsic immune response to KSHV infection.
Not available
S-EPMC6242832 | biostudies-literature
UnknownZFC3H1 and U1-70K promote the nuclear retention of mRNAs with 5' splice site motifs within nuclear speckles.
Not available
S-EPMC9074902 | biostudies-literature
UnknownLENG8 mediates RNA nuclear retention and degradation in eukaryotes.
Not available
S-EPMC12363940 | biostudies-literature
UnknownIsoform characterization of m<sup>6</sup>A in single cells identifies its role in RNA surveillance.
Not available
S-EPMC12219666 | biostudies-literature
GenomicsErroneous ribosomal RNAs promote the generation of antisense ribosomal siRNA
Erroneous ribosomal RNAs promote the generation of antisense ribosomal siRNA
PRJNA454449 | ENA
UnknownN-6-methyladenosine (m6A) promotes the nuclear retention of mRNAs with intact 5' splice site motifs.
Not available
S-EPMC11629677 | biostudies-literature
UnknownErroneous ribosomal RNAs promote the generation of antisense ribosomal siRNA.
Not available
S-EPMC6176571 | biostudies-literature
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