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TranscriptomicsRegulation of alternative splicing by histone modifications
Alternative splicing of pre-mRNA is a prominent mechanism to generate protein diversity, yet its regulation is poorly understood. Here, we demonstrate a direct role for histone modifications in alternative splicing. We find distinctive histone modification signatures which correlate with splicing ou...
ORGANISM(S): Homo sapiens 
2010-02-10 | E-GEOD-19373 | biostudies-arrayexpress
TranscriptomicsExpression data from immortalized and transformed WT and HGPS cell lines
Primary skin fibroblasts from HGPS patients and an age-matched control wild-type individuals were challenged in a standard transformation assay by retroviral introduction of TERT (T), V12-HRAS (R) and SV40 large and small T antigens (S). TERT-Immortalized cell lines from the same sources were also g...
ORGANISM(S): Homo sapiens 
2014-10-02 | E-GEOD-60518 | biostudies-arrayexpress
TranscriptomicsExpression data from transformed WT and HGPS cell lines, including HGPS cells after knock-down of BRD4
Primary skin fibroblasts from a HGPS patient and an age-matched control wild-type individual were challenged in a standard transformation assay by retroviral introduction of TERT (T), V12-HRAS (R) and SV40 large and small T antigens (S). Knock-down of BRD4 in this TRS-HGPS cell line (TRS-HGPS-shBRD4...
ORGANISM(S): Homo sapiens 
2014-10-02 | E-GEOD-60519 | biostudies-arrayexpress
UnknownHiIDDD: a high-throughput imaging pipeline for the quantitative detection of DNA damage in primary human immune cells.
Not available
S-EPMC9022135 | biostudies-literature
UnknownLocus-specific and activity-independent gene repositioning during early tumorigenesis.
Not available
S-EPMC2213600 | biostudies-literature
UnknownThe lamin protein family.
Not available
S-EPMC3219962 | biostudies-literature
UnknownHiPLA: High-throughput imaging proximity ligation assay.
Not available
S-EPMC6401276 | biostudies-literature
UnknownA high-throughput DNA FISH protocol to visualize genome regions in human cells.
Not available
S-EPMC8377592 | biostudies-literature
UnknownLINC complexes in health and disease.
Not available
S-EPMC3035119 | biostudies-literature
UnknownNuclear position modulates long-range chromatin interactions.
Not available
S-EPMC9581366 | biostudies-literature
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