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TranscriptomicsRegulation of alternative splicing by histone modifications
Alternative splicing of pre-mRNA is a prominent mechanism to generate protein diversity, yet its regulation is poorly understood. Here, we demonstrate a direct role for histone modifications in alternative splicing. We find distinctive histone modification signatures which correlate with splicing ou...
ORGANISM(S): Homo sapiens 
2010-02-10 | E-GEOD-19373 | biostudies-arrayexpress
UnknownExpression data from immortalized and transformed WT and HGPS cell lines
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-60518 | biostudies-other
UnknownExpression data from transformed WT and HGPS cell lines, including HGPS cells after knock-down of BRD4
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-60519 | biostudies-other
TranscriptomicsExpression data from immortalized and transformed WT and HGPS cell lines
Primary skin fibroblasts from HGPS patients and an age-matched control wild-type individuals were challenged in a standard transformation assay by retroviral introduction of TERT (T), V12-HRAS (R) and SV40 large and small T antigens (S). TERT-Immortalized cell lines from the same sources were also g...
ORGANISM(S): Homo sapiens 
2014-10-02 | E-GEOD-60518 | biostudies-arrayexpress
GenomicsBRD4 binding sites in transformed fibroblasts
Analysis of BRD4 ChIP-seq data of two types of human transformed fibroblasts (WT and HGPS) to identify specific and common binding sites for BRD4. Transformed cell lines were obtained by retroviral introduction of TERT (T), V12-HRAS (R) and SV40 large and small T antigens (S) of primary skin fibrobl...
ORGANISM(S): Homo sapiens 
2014-10-02 | E-GEOD-61325 | biostudies-arrayexpress
TranscriptomicsExpression data from transformed WT and HGPS cell lines, including HGPS cells after knock-down of BRD4
Primary skin fibroblasts from a HGPS patient and an age-matched control wild-type individual were challenged in a standard transformation assay by retroviral introduction of TERT (T), V12-HRAS (R) and SV40 large and small T antigens (S). Knock-down of BRD4 in this TRS-HGPS cell line (TRS-HGPS-shBRD4...
ORGANISM(S): Homo sapiens 
2014-10-02 | E-GEOD-60519 | biostudies-arrayexpress
TranscriptomicsEFV-miRNA
Background: LINE-1 elements make up the most abundant retrotransposon family in the human genome. Full-length LINE-1 elements encode their own reverse transcriptase (RT). They are expressed at low levels in normal cells and abundantly in cancer cells. RT down-regulation, by either RNA interference t...
ORGANISM(S): Homo sapiens 
2014-01-01 | E-MTAB-1737 | biostudies-arrayexpress
TranscriptomicsEFV-GE
Background: LINE-1 elements make up the most abundant retrotransposon family in the human genome. Full-length LINE-1 elements encode their own reverse transcriptase (RT). They are expressed at low levels in normal cells and abundantly in cancer cells. RT down-regulation, by either RNA interference t...
ORGANISM(S): Homo sapiens 
2014-01-01 | E-MTAB-1735 | biostudies-arrayexpress
TranscriptomicsEFV-UCR
Background: LINE-1 elements make up the most abundant retrotransposon family in the human genome. Full-length LINE-1 elements encode their own reverse transcriptase (RT). They are expressed at low levels in normal cells and abundantly in cancer cells. RT down-regulation, by either RNA interference t...
ORGANISM(S): Homo sapiens 
2014-01-01 | E-MTAB-1736 | biostudies-arrayexpress
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