Sort   by:  
 Page size 
UnknownNoradrenergic Transmission at Alpha1-Adrenergic Receptors in the Ventral Periaqueductal Gray Modulates Arousal.
Not available
S-EPMC6326840 | biostudies-literature
TranscriptomicsTranscription profiling of lung and liver from low and high dose Perfluorooctanoic Acid exposed fetuses
Exposure to PFOA during gestation altered the expression of genes related to fatty acid catabolism in both the fetal liver and lung. In the fetal liver, the effects of PFOA were robust and also included genes associated with lipid transport, ketogenesis, glucose metabolism, lipoprotein metabolism, ...
ORGANISM(S): Mus musculus 
2008-10-26 | E-GEOD-13044 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse fetus exposed to lung and liver of Perfluorooctane sulfonate (PFOS)
Most of the transcriptional changes induced by PFOS in the fetal mouse liver and lung were related to activation of PPARalpha. When compared to the transcript profiles induced by PFOA (Pubmed ID 17681415), few remarkable differences were found other than up-regulation of Cyp3a genes. Because PFOS ...
ORGANISM(S): Mus musculus 
2009-05-16 | E-GEOD-13302 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of G1E cells which are Gata-1 erythroid-committed cell line derived from targeted disruption of Gata-1 in embryonic stem cells to study the global regulation of erythroid gene expression by transcription factor GATA-1
G1E cells are a Gata-1 erythroid-committed cell line derived from targeted disruption of Gata-1 in embryonic stem cells. The ER4 subclone contains an inducible form of Gata-1 (Gata-1-ER, Gata-1 fused to the estradiol receptor ligand binding domain). We performed transcriptome analysis using this cel...
ORGANISM(S): Mus musculus 
2007-12-15 | E-GEOD-628 | biostudies-arrayexpress
MetabolomicsSCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia
Acute myeloid leukemia (AML) cells rely on phospho-signaling pathways to gain unlimited proliferation potential. Here, we used domain-focused CRISPR screening to identify the nuclear phosphatase SCP4 as a dependency in AML, yet this enzyme is dispensable in normal hematopoietic progenitor cells. Usi...
2025-05-29 | MTBLS3707 | MetaboLights
TranscriptomicsA High-Fat Diet and NAD+ Rescue Premature Aging in Cockayne Syndrome
Cockayne syndrome (CS) is an accelerated aging disorder characterized by progressive neurodegeneration caused by mutations in the genes encoding the DNA repair proteins CSA or CSB. Csbm/m mice were given a high-fat, caloric-restricted or resveratrol-supplemented diet. The high-fat diet rescued the p...
ORGANISM(S): Mus musculus 
2014-12-22 | E-GEOD-62194 | biostudies-arrayexpress
ProteomicsProteomics-based insights into mitogen-activated protein kinase inhibitor resistance of cerebral melanoma metastases
Background MAP kinase inhibitor (MAPKi) therapy for BRAF mutated melanoma is characterized by high response rates but also development of drug resistance within a median progression-free survival (PFS) of 9 to 12 months. Understanding mechanisms of resistance and identifying effective therapeutic al...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000082948 | MassIVE
TranscriptomicsBenign Copy Number Changes in Clinical Cytogenetic Diagnostics by Array CGH
A database of apparently benign copy number variants (bCNVs) detected by a Spectral Genomics Inc./PerkinElmer BAC array platform has been maintained through the University of Utah Comparative Genomic Hybridization laboratory since 2005. The target population for this database represents 1275 patien...
ORGANISM(S): Homo sapiens 
2008-08-31 | E-GEOD-11815 | biostudies-arrayexpress
ProteomicsCathepsin B MSP-MS at pH 4.6 and 7.2 without inhibitor
MSP-MS of Cathepsin B at pH 4.6 and pH 7.2 without inhibitor
ORGANISM(S): Synthetic Construct (ncbitaxon:32630) 
2020-11-12 | MSV000086449 | MassIVE
ProteomicsCathepsin B MSP-MS at pH 4.6 and pH 7.2
MSP-MS of Cathepsin B protease at acidic and neutral pH
ORGANISM(S): Synthetic Construct (ncbitaxon:32630) 
2020-11-12 | MSV000086447 | MassIVE
Sort   by:  
 Page size