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UnknownHaploinsufficiency of ITSN1 is associated with a substantial increased risk of Parkinson's disease.
Not available
S-EPMC12124131 | biostudies-literature
GenomicsDiurnal changes of HDAC3, Rev-erbα, NCoR and Pol II recruitment to the mouse liver genome and of H3K9Ac
We reported a diurnal changes in the recruitment of HDAC3, Rev-erbα, NCoR and Pol II to the mouse liver genome as well as H3K9 acetylation in vivo at ZT10 and ZT22. ChIP-Seq profiling of HDAC3, Rev-erbα, NCoR and Pol II binding and H3K9Ac in mouse liver harvested at 2 different times (ZT10 and ZT22)...
ORGANISM(S): Mus musculus 
2011-03-11 | E-GEOD-26345 | biostudies-arrayexpress
TranscriptomicsGene expression in mouse liver depleted of HDAC3
Liver-specific depletion of HDAC3 leads to liver steatosis (fatty liver), suggesting disregulation of lipid metabolism. This is correlated with changes in lipid metabolic gene expression. Livers depleted of HDAC3 were removed from 12 week old male HDAC3 fl/fl mice (loxP sites flanking exon 4 to 7 of...
ORGANISM(S): Mus musculus 
2011-03-11 | E-GEOD-25937 | biostudies-arrayexpress
UnknownmicroRNA alterations driving acute and late stages of radiation-induced fibrosis in a murine skin model.
Not available
S-EPMC7665809 | biostudies-literature
UnknownCD44 is prognostic for overall survival in the NCI randomized trial on breast conservation with 25 year follow-up.
Not available
S-EPMC7668685 | biostudies-literature
TranscriptomicsCircadian Enhancers Coordinate Multiple Phases of Rhythmic Gene Transcription In Vivo
Mammalian transcriptomes display complex circadian rhythms with multiple phases of gene expression that cannot be accounted for by current models of the molecular clock.  We have determined the underlying mechanisms by measuring nascent RNA transcription around the clock in mouse liver. Unbiased ex...
ORGANISM(S): Mus musculus 
2015-01-06 | E-GEOD-59460 | biostudies-arrayexpress
UnknownSpatial mapping of the DNA adducts in cancer.
Not available
S-EPMC10330576 | biostudies-literature
UnknownHigh-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations.
Not available
S-EPMC7002524 | biostudies-literature
TranscriptomicsEffects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice
Calorie restriction (CR) is the most robust non-genetic intervention to universally delay the onset of age-related diseases and extend mean and maximum lifespan. However, species, strain, sex, diet, age of onset, and level of CR are emerging as important variables to consider for a successful CR res...
ORGANISM(S): Mus musculus 
2016-06-27 | E-GEOD-81959 | biostudies-arrayexpress
TranscriptomicsDiscrete Functions of Rev-erba Couple Metabolism to the Clock [array]
Circadian and metabolic physiology are intricately intertwined, as illustrated by Rev-erb , a transcription factor (TF) that functions both as a core repressive component of the cell autonomous clock and as a regulator of metabolic genes. Here we show that Rev-erb modulates the clock and metabolis...
ORGANISM(S): Mus musculus 
2015-06-16 | E-GEOD-67964 | biostudies-arrayexpress
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