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UnknownCommunicating uncertainty about facts, numbers and science.
Not available
S-EPMC6549952 | biostudies-literature
GenomicsPropagation of Adipogenic Signals through an Epigenomic Transition State
The transcriptional mechanisms by which temporary exposure to developmental signals instigates adipocyte differentiation are unknown. During early adipogenesis, we find transient enrichment of the glucocorticoid receptor (GR), CCAAT/enhancer binding protein b (CEBPb), p300, mediator subunit 1, and h...
ORGANISM(S): Mus musculus 
2010-05-20 | E-GEOD-21898 | biostudies-arrayexpress
UnknownGanitumab (AMG 479) inhibits IGF-II-dependent ovarian cancer growth and potentiates platinum-based chemotherapy.
Not available
S-EPMC4138720 | biostudies-literature
GenomicsEpigenome in brown and white adipose tissue
For comparative epigenomic analysis of brown fat and white fat in mice, H3K27ac and PolII ChIP-seq were performed in each depot. H3K27ac histone modification and PolII transcription profiles in mouse brown and white adipose tissues
ORGANISM(S): Mus musculus 
2015-02-10 | E-GEOD-63964 | biostudies-arrayexpress
TranscriptomicsThe Nuclear Receptor Rev-erb alpha Regulates Adipose Tissue-Specific FGF21 Signaling (Microarray)
To investigate the role of the transcriptional repressor Rev-erb alpha in epididymal white adipose tissue, we performed a microarray analysis of gene expression in the epididymal white adipose tissue of wildtype and Rev-erb alpha knock-out mice. Examination of the transcriptome in epididymal white a...
ORGANISM(S): Mus musculus 
2016-07-20 | E-GEOD-79164 | biostudies-arrayexpress
GenomicsHistone Deacetylase 3 is an Epigenomic Brake in Macrophage Alternative Activation (ChIP-Seq)
We report the genomic regions enriched in Histone Deacetylase 3 (HDAC3) in mouse bone marrow derived macrophages. Furthermore, we also report the genomic acetylation pattern on Histone 3, Lysine 9 (H3K9) in macrophages with and without HDAC3 and/or treated with Th2 cytokine IL-4. HDAC3 enriched gen...
ORGANISM(S): Mus musculus 
2011-11-10 | E-GEOD-33596 | biostudies-arrayexpress
UnknownHuman DNA methylation signatures differentiate persistent from resolving MRSA bacteremia.
Not available
S-EPMC7958259 | biostudies-literature
ProteomicsPLpro inhibition protects in post-acute sequelae mouse model of COVID-19
The COVID-19 pandemic has highlighted how vulnerable a globally connected population is to the threat of newly emerging zoonotic viruses, exemplified by SARS-CoV-2. Despite considerable efforts to identify antivirals for coronaviruses (CoVs) in the last two decades, there exists only one FDA-approve...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-23 | PXD054356 | Pride
Sars-cov-2  long covid  pasc  inflammation 
TranscriptomicsTranscriptomic response of murine liver to severe injury and hemorrhagic shock: CodeLink portion of dual platform
A dual platform microarray analysis was used to characterize the temporal transcriptomic response in the mouse liver following trauma and hemmorhagic shock Mice were divided into five groups, anesthetized and surgically treated to simulate a time course and trauma severity model: non-manipulated ani...
ORGANISM(S): Mus musculus 
2011-01-24 | E-GEOD-26696 | biostudies-arrayexpress
TranscriptomicsTranscriptomic response of murine liver to severe injury and hemorrhagic shock
This SuperSeries is composed of the following subset Series: GSE26695: Transcriptomic response of murine liver to severe injury and hemorrhagic shock: Affymetrix portion of dual platform GSE26696: Transcriptomic response of murine liver to severe injury and hemorrhagic shock: CodeLink portion of dua...
ORGANISM(S): Mus musculus 
2011-01-24 | E-GEOD-26697 | biostudies-arrayexpress
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