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UnknownMitchell-Riley Syndrome: Improving Clinical Outcomes and Searching for Functional Impact of RFX-6 Mutations.
Not available
S-EPMC9257252 | biostudies-literature
UnknownGPR55 deficiency is associated with increased adiposity and impaired insulin signaling in peripheral metabolic tissues.
Not available
S-EPMC6355063 | biostudies-literature
TranscriptomicsTranscription profiling of lung and liver from low and high dose Perfluorooctanoic Acid exposed fetuses
Exposure to PFOA during gestation altered the expression of genes related to fatty acid catabolism in both the fetal liver and lung. In the fetal liver, the effects of PFOA were robust and also included genes associated with lipid transport, ketogenesis, glucose metabolism, lipoprotein metabolism, ...
ORGANISM(S): Mus musculus 
2008-10-26 | E-GEOD-13044 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse fetus exposed to lung and liver of Perfluorooctane sulfonate (PFOS)
Most of the transcriptional changes induced by PFOS in the fetal mouse liver and lung were related to activation of PPARalpha. When compared to the transcript profiles induced by PFOA (Pubmed ID 17681415), few remarkable differences were found other than up-regulation of Cyp3a genes. Because PFOS ...
ORGANISM(S): Mus musculus 
2009-05-16 | E-GEOD-13302 | biostudies-arrayexpress
UnknownFactual text and emotional pictures: overcoming a false dichotomy of cigarette warning labels.
Not available
S-EPMC5650578 | biostudies-literature
UnknownClinical Activity of the γ-Secretase Inhibitor PF-03084014 in Adults With Desmoid Tumors (Aggressive Fibromatosis).
Not available
S-EPMC5455706 | biostudies-literature
UnknownBiological characterization of the hygrobafilomycin antibiotic JBIR-100 and bioinformatic insights into the hygrolide family of natural products.
Not available
S-EPMC5108699 | biostudies-literature
TranscriptomicsSelective inhibition of Homo sapiens M1 macrophages where SP140 mRNA is inhibited using siRNA
As part of our study in understanding the role of SP140 in inflammatory pathways in macrophages, we inhibited SP140 mRNA using siRNA. Peripheral blood mononuclear cells (PBMCs) were obtained from whole blood of healthy donors (from Sanquin Institute Amsterdam or from GSK Stevenage Blood Donation U...
ORGANISM(S): Homo sapiens 
2022-07-22 | E-MTAB-12011 | biostudies-arrayexpress
MetabolomicsMetabolic profiling of rheumatoid arthritis neutrophils reveals altered energy metabolism that is not affected by JAK inhibition
Neutrophils play a key role in the pathophysiology of rheumatoid arthritis (RA) where release of ROS and proteases directly causes damage to joints and tissues. Neutrophil function is directly affected by Janus Kinase (JAK) inhibitor drugs, including tofacitinib and baricitinib, which are clinically...
2023-07-11 | MTBLS4766 | MetaboLights
UnknownStress-induced Norepinephrine Downregulates CCL2 in Macrophages to Suppress Tumor Growth in a Model of Malignant Melanoma.
Not available
S-EPMC7607650 | biostudies-literature
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