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ProteomicsKinome profiling of shControl and shFANCA THP1 cells treated with volasertib
The Fanconi anemia (FA) pathway is a network of proteins critical to the preservation of genomic integrity and the prevention of cancer. FA proteins safeguard the genome by regulating the cell cycle and facilitating error-free repair of DNA damage. Bi-allelic mutation of genes encoding FA pathway pr...
ORGANISM(S): Homo sapiens (Human) 
2024-11-21 | PXD048057 | Pride
Polo-like kinase 1 Kinase inhibitor Acute myeloid leukemia Fanconi anemia 
UnknownA single amino acid substitution in the envelope protein of chimeric yellow fever-dengue 1 vaccine virus reduces neurovirulence for suckling mice and viremia/viscerotropism for monkeys.
Not available
S-EPMC514991 | biostudies-literature
ProteomicsKinome profiling of shControl and shFANCA HL60 cells treated with volasertib
The Fanconi anemia (FA) pathway is a network of proteins critical to the preservation of genomic integrity and the prevention of cancer. FA proteins safeguard the genome by regulating the cell cycle and facilitating error-free repair of DNA damage. Bi-allelic mutation of genes encoding FA pathway pr...
ORGANISM(S): Homo sapiens (Human) 
2024-11-21 | PXD048014 | Pride
Polo-like kinase 1 Kinase inhibitor Acute myeloid leukemia Fanconi anemia 
UnknownPLK1 Inhibition Induces Synthetic Lethality in Fanconi Anemia Pathway-Deficient Acute Myeloid Leukemia.
Not available
S-EPMC12011380 | biostudies-literature
ProteomicsPLK1 inhibition induces synthetic lethality in Fanconi anemia pathway-deficient acute myeloid leukemia
Overall survival of acute myeloid leukemia (AML) remains limited. Inhibitors of the master mitotic kinase PLK1 have emerged as promising therapeutics, demonstrating efficacy in an undefined subset of AML patients. However, the clinical success of PLK1 inhibitors remains hindered by a lack of predict...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-12-09 | MSV000096625 | MassIVE
UnknownSpatial Gene-Expression Profiling Unveils Immuno-oncogenic Programs of NF1-Associated Peripheral Nerve Sheath Tumor Progression.
Not available
S-EPMC11095977 | biostudies-literature
UnknownImproved reference genome of Aedes aegypti informs arbovirus vector control.
Not available
S-EPMC6421076 | biostudies-literature
UnknownThe Use of TKM-100802 and Convalescent Plasma in 2 Patients With Ebola Virus Disease in the United States.
Not available
S-EPMC4542597 | biostudies-literature
UnknownSocializing One Health: an innovative strategy to investigate social and behavioral risks of emerging viral threats.
Not available
S-EPMC8122533 | biostudies-literature
UnknownBaseline predictors for one-year visual outcomes with ranibizumab or bevacizumab for neovascular age-related macular degeneration.
Not available
S-EPMC3536921 | biostudies-literature
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