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ProteomicsA Multi-Omic Analysis of Human Naive CD4 T cells
Technological advances in genomics, epigenomics, transcriptomics and proteomics have enabled massively parallel measurements across thousands of genes and gene products. Such high-throughput technologies have been extensively used to carry out genome-wide studies particularly in the context of disea...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-04-04 | MSV000079624 | MassIVE
ProteomicsA Multi-Omic Analysis of Human Naive CD4 T cells
Technological advances in genomics, epigenomics, transcriptomics and proteomics have enabled massively parallel measurements across thousands of genes and gene products. Such high-throughput technologies have been extensively used to carry out genome-wide studies particularly in the context of disea...
ORGANISM(S): Homo sapiens (Human) 
2015-11-12 | PXD000376 | Pride
Naive cd4+ t cells Memory cd4+ t cells Lc-msms 
TranscriptomicsTranscription profiling of mouse spleen after immunized using LPS vs MPL as adjuvant.
An unresolved issue in immunology is the extent to which inflammatory effects are needed for robust T cell responses. In this study, mice were immunized by iv injection using either high toxicity lipopolysaccharide (LPS) or low toxicity monophosphoryl lipid A (MPL) as adjuvant. Six hours after iv ...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7768 | biostudies-arrayexpress
TranscriptomicsRheumatoid arthritis and anti-TNF treatment
In 15 patients with rheumatoid arthritis the baseline expression (t=0) of type I IFN-regulated genes was determined in peripheral blood cells (PAXgene) using cDNA-microarrays and compared to levels one month after (t=1) anti-TNF treatment (infliximab). Therefore, we used 43K cDNA microarrays from th...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-19821 | biostudies-arrayexpress
ProteomicsLabel-free proteome analysis of small extracellular vesicles (sEV) expressing different HRS mutants.
Label-free proteome analysis of small extracellular vesicles (sEV) derived from WM9 cells expressing different HRS mutants: wild type (HRSWT), phospho-deficient (HRSS345A), and phospho-mimetic mutant HRS (HRSS345D).
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-02-16 | MSV000088846 | MassIVE
TranscriptomicsTranscription profiling of mouse small intestine intraepithelial lymphocytes (IEL) vs. TCR ab+ CD8b+ and TCR gd+ cells
Mouse small intestine intraepithelial lymphocytes (IEL) that express a ab TCR and CD8aa homodimers are an enigmatic T cell subset, as their specificity and in vivo function remain to be defined. To gain insight into the nature of these cells, we performed global gene expression profiling using micr...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5355 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of H. pylori stationary (Stat Chelate and Stat.iron.survival)and exponential (Log Chelate and Log.iron.survival) subjected to chelation using DPP
This data set was used to determine genes that are regulated by iron availability and to access the growth phase dependence on that regulation. Stationary (Stat Chelate and Stat.iron.survival)and exponential (Log Chelate and Log.iron.survival)were subjected to chelation using DPP. Growth status of...
ORGANISM(S): Helicobacter pylori 
2005-10-14 | E-SMDB-2267 | biostudies-arrayexpress
TranscriptomicsGrowth phase-dependent response of Helicobacter pylori to iron starvation.
This data set was used to determine genes that are regulated by iron availability and to access the growth phase dependence on that regulation. Stationary (Stat Chelate and Stat.iron.survival)and exponential (Log Chelate and Log.iron.survival)were subjected to chelation using DPP. Growth status of...
ORGANISM(S): Helicobacter pylori 
2005-12-21 | E-GEOD-3888 | biostudies-arrayexpress
UnknownOrally administered particulate beta-glucan modulates tumor-capturing dendritic cells and improves antitumor T-cell responses in cancer.
Not available
S-EPMC2970627 | biostudies-literature
TranscriptomicsDifferential gene expression in WT mice and mice lacking PTPN2 in T cells
WT mice and mice lacking PTPN2 in T cells (PTPN2-CD4Cre mice) were treated with AOM/DSS to induce colorectal tumours. RNA was isolated from tumour and non-tumour tissues in the colon. Colon samples from water-treated WT and PTPN2-CD4Cre mice served as additional control. Total RNA was isolated and t...
ORGANISM(S): Mus musculus 
2020-10-03 | E-MTAB-9629 | biostudies-arrayexpress
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