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TranscriptomicsTranscription profiling of human colon Caco-2 cells treated with sulforaphane (SF)
Effect of sulforaphane (SF) on human colon caco-2 cells after 24h treatment
ORGANISM(S): Homo sapiens 
2005-07-01 | E-MEXP-170 | biostudies-arrayexpress
TranscriptomicsRNA-seq experiment to investigate the effect sulforaphane metabolism in HepG2 cells (human hepatocellular carcinoma cell lines). Cells treated with sulforaphane were compared against untreated cells in three different glucose environments: no glucose, basal and high glucose, to study the transcriptional effect of sulforaphane on liver cells at different metabolic states.
Over the past six years, literature has shown that sulforaphane (SF) can affect a wide range of genes involved in central metabolism, such as glycolysis, pentose phosphate pathway, TCA cycle, lipid biosynthesis and oxidation. In this experiment, RNA sequencing was performed on HepG2 cells in three g...
ORGANISM(S): Homo sapiens 
2024-03-30 | E-MTAB-12851 | biostudies-arrayexpress
TranscriptomicsRNA-seq experiment to investigate the impact of sulforaphane metabolism in HepG2 cells. Cells with NRF2 knockdown treated with sulforaphane were compared to untreated cells with NRF2 knock-down. Similarly, wild type cells treated with sulforaphane were compared to untreated cells.
This study aims to assess whether genes involved in central metabolism induced by Sulforaphane, SF, are mediated through the transcription factor NRF2. A time course RNA-seq experiment was performed, where RNA is extracted after 3, 9, and 24 hours SF treatment. This experiment tests the following hy...
ORGANISM(S): Homo sapiens 
2024-03-30 | E-MTAB-12858 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human colon Caco2 cells treated with extracts from broccoli that had been cooked for different lengths of time
Caco2 cells were treated 24 hours with broccoli extracts that had been cooked for different lengths of time.
ORGANISM(S): Homo sapiens 
2008-09-30 | E-MEXP-1372 | biostudies-arrayexpress
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