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MetabolomicsOPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response

Ferroptosis, an iron-dependent form of nonapoptotic cell death mediated by lipid peroxidation, has been implicated in the pathogenesis of multiple diseases. Subcellular organelles play pivotal roles in the regulation of ferroptosis, but the mechanisms underlying the contributions of the mitochond...

2025-07-14 | MTBLS10544 | MetaboLights
ProteomicsThe Small GTPase Rab7 Regulates Release of Mitochondria in Extracellular Vesicles in Response to Lysosomal Dysfunction
Deletion of the small GTPase Rab7 in cells or adult mouse heart leads to increased secretion of EVs containing ubiquitinated cargos, including intact mitochondria. Mass spectrometry data of extracellular vesicles was obtained for proteomics.
ORGANISM(S): Mus musculus (Mouse) 
2023-08-22 | PXD037992 | Pride
Extracellular vesicles Mitochondria 
UnknownNeurolastin, a dynamin family GTPase, translocates to mitochondria upon neuronal stress and alters mitochondrial morphology in vivo.
Not available
S-EPMC6663861 | biostudies-literature
UnknownA Mitofusin-2-dependent inactivating cleavage of Opa1 links changes in mitochondria cristae and ER contacts in the postprandial liver.
Not available
S-EPMC4234614 | biostudies-literature
TranscriptomicsMitochondria help avoid glucose addiction in cancer cells
Cancer cells consume large amounts of glucose because of their specific metabolic pathway. However, cancer cells exist in tumor tissue where glucose is insufficient. To survive, cancer cells likely have the mechanism to elude their glucose addiction. Here we show that functional mitochondria are ess...
ORGANISM(S): Homo sapiens 
2010-05-28 | E-GEOD-16157 | biostudies-arrayexpress
UnknownThe ERA-Related GTPase AtERG2 Associated with Mitochondria 18S RNA Is Essential for Early Embryo Development in Arabidopsis.
Not available
S-EPMC5818394 | biostudies-literature
ProteomicsIn vivo identification of GTPase interactors by mitochondrial relocalizationand proximity biotinylation
The ~160 small GTPases that comprise the Ras superfamily include many major regulators of growth, membrane traffic and the cytoskeleton, and a wide range of diseases are caused by mutations in particular members. They function as switchable landmarks with the active GTP-bound form recruiting to the ...
ORGANISM(S): Homo sapiens (Human) 
2019-07-17 | PXD013668 | Pride
Human Mitochondria gtpase Bira* Ras Lc-ms/ms Membranes Gefs 
UnknownThe Small GTPase Cdc42 Negatively Regulates the Formation of Neutrophil Extracellular Traps by Engaging Mitochondria.
Not available
S-EPMC7925625 | biostudies-literature
TranscriptomicsRat Life Cycle (RLC) Heart Gene Expression Data
Cardiovascular disease (CVD) is the leading cause of mortality, with sex and age being strong risk factors. Mitochondria are vital for normal cardiac function, and regulation of mitochondrial structure and function may impact susceptibility to CVD. We analyzed the basal expression levels of mitocho...
ORGANISM(S): Rattus norvegicus 
2014-09-30 | E-GEOD-58204 | biostudies-arrayexpress
UnknownDrp1 Tubulates the ER in a GTPase-Independent Manner.
Not available
S-EPMC7680448 | biostudies-literature
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