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MetabolomicsDeficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease
Non-alcoholic fatty liver is the most common liver disease worldwide. Here, we show that the mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease. Reduced Mfn2 expression was detected in liver biopsies from patients with non-alcoholic steatohepatitis (NASH). Moreover, reduced Mfn2...
2018-01-25 | MTBLS600 | MetaboLights
MetabolomicsControlling mitochondrial membrane architecture via MIC60 determines viral replication to promote anti-viral immunity
Virus-infected cells often exhibit dramatic cellular changes accompanied by altered mitochondrial function. The contribution of factors shaping the inner mitochondrial membrane (IMM) and cristae architecture on viral replication is insufficiently understood. Single cell transcriptomics applying vesi...
2025-06-24 | MTBLS12437 | MetaboLights
GenomicsDisruption of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) integrity identified in FUS‑mutant oligodendroglial progeny from human induced pluripotent stem cells
Disruption of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) integrity identified in FUS‑mutant oligodendroglial progeny from human induced pluripotent stem cells
PRJNA999223 | ENA
Proteomicsproteomic analysis of mitochondria-associated endoplasmic reticulum membrane in a Parkinson’s disease mouse model
In subacute MPTP mouse models, Nano ultra-high performance liquid chromatography-tandem mass spectrum and bioinformatic analysis were adopted to obtain the underlying molecular data of MAM fractions, providing valuable insights into its potential role in PD pathogenesis.
ORGANISM(S): Mus Musculus 
2024-04-26 | PXD051805 |
MetabolomicsNatural photosynthetic system for restoring homeostasis of animal organelle interaction network

Disruption of organelle interactions due to metabolic stress is a crucial factor in the pathological processes of many degenerative diseases. Current treatments usually focus on individual organelles while ignoring the role of organelle interactions in cell damage caused by cascade reactions. The...

2026-01-20 | MTBLS13730 | MetaboLights
UnknownMitochondria-associated endoplasmic reticulum membrane (MAM)-associated calpains system in preeclampsia.
Not available
S-EPMC12553276 | biostudies-literature
ProteomicsLiver mitochondria-associated ER membrane proteomics for studying the effects of ZiBuPiYin recipe on Zucker diabetic fatty rats after chronic psychological stress
Type 2 diabetes mellitus (T2DM) is a complex metabolic disease with multiple etiologies, involving both genetic and environmental factors. With changes associated with modern life, increasing attention has been paid to chronic psychological stressors such as work stress. Chronic psychological stress...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-10-25 | PXD029226 | Pride
Type 2 diabetes mellitus Chronic psychological stress Zibupiyin recipe Proteomics Mitochondria-associated er membrane 
ProteomicsThe plasma membrane, casein-containing vesicles and endoplasmic reticulum are the main membrane contributors to milk fat globule membrane formation
During lactation, mammary epithelial secretory cells secrete huge amounts of milk from their apical side. The major milk proteins, the caseins, are secreted by exocytosis, while milk fat globules are released by budding, enwrapped by the plasma membrane. Due to the number and large size of milk fat ...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-19 | PXD001024 | Pride
Mouse Mfgm Lc-ms/ms 
UnknownTitanium Dioxide Nanoparticles Induce Endoplasmic Reticulum Stress-Mediated Autophagic Cell Death via Mitochondria-Associated Endoplasmic Reticulum Membrane Disruption in Normal Lung Cells.
Not available
S-EPMC4485469 | biostudies-literature
TranscriptomicsDisruption of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) integrity identified in FUS‑mutant oligodendroglial progeny from human induced pluripotent stem cells
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive, fatal neurodegenerative disorder, characterized by selective loss of motor neurons (MNs). A number of causative genetic mutations underlie the disease, including mutations in the fused in sarcoma (FUS) gene, which can lead to both juvenil...
ORGANISM(S): Homo sapiens 
2024-01-01 | GSE239403 | GEO
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