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ProteomicsProximity proteomics reveals a mechanism of fatty acid transfer at lipid droplet-mitochondria- endoplasmic reticulum contact sites
Membrane contact sites between organelles are critical for transfer of biomolecules. Lipid droplets store fatty acids and form contacts with mitochondria, which regulate fatty acid oxidation and adenosine triphosphate production. Protein compartmentalization at lipid droplet-mitochondria contact sit...
ORGANISM(S): Homo sapiens (Human) 
2025-04-28 | PXD060912 | Pride
Lipid droplet Fatty acid Lipid metabolism Lipidomics Lipotoxicity Mitochondria Cell metabolism 
ProteomicsA Proximity Labeling Strategy Provides Insights into the Composition and Dynamics of mitochondria-lipid droplet contact proteomes
Accumulating studies have shown that mitochondria-lipid droplet (LD) interaction is crucial for maintaining the homeostasis of lipid metabolism in the liver. However, the proteins involved in mitochondria-LD interaction and the functioning mechanism remain largely elusive. Here, we applied a systema...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD035813 | Pride
Cholesterol Bifc Comparative proteomics Proximity labeling Mitochondria-lipid droplet contact 
UnknownProximity proteomics reveals a mechanism of fatty acid transfer at lipid droplet-mitochondria- endoplasmic reticulum contact sites.
Not available
S-EPMC11876333 | biostudies-literature
UnknownEzetimibe Enhances Lipid Droplet and Mitochondria Contact Formation, Improving Fatty Acid Transfer and Reducing Lipotoxicity in Alport Syndrome Podocytes.
Not available
S-EPMC11642288 | biostudies-literature
UnknownLong-term live-cell lipid droplet-targeted biosensor development for nanoscopic tracking of lipid droplet-mitochondria contact sites.
Not available
S-EPMC8315056 | biostudies-literature
UnknownPLIN5 interacts with FATP4 at membrane contact sites to promote lipid droplet-to-mitochondria fatty acid transport.
Not available
S-EPMC10525032 | biostudies-literature
UnknownORP5 and ORP8 orchestrate lipid droplet biogenesis and maintenance at ER-mitochondria contact sites.
Not available
S-EPMC9375143 | biostudies-literature
UnknownSpatially resolved rewiring of mitochondria-lipid droplet interactions in hepatic lipid homeostasis.
Not available
S-EPMC11722523 | biostudies-literature
UnknownInteractomic study on interaction between lipid droplets and mitochondria.
Not available
S-EPMC4875178 | biostudies-literature
TranscriptomicsPPARa regulates ER-lipid droplet protein Calsyntenin-3b to promote ketogenesis in hepatocytes
Ketogenesis requires fatty acid flux from intrahepatic (lipid droplets) and extrahepatic (adipose tissue) lipid stores to hepatocyte mitochondria. However, whether inter-organelle contact sites regulate this process is unknown. Recent studies have revealed a role for Calsyntenin-3b (CLSTN3b), an end...
ORGANISM(S): Mus musculus 
2025-04-02 | GSE289761 | GEO
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