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ProteomicsMitochondrial VHL rewires cell metabolism in hypoxia
Under normoxia, von Hippel-Lindau (VHL) protein targets the oxygen-induced, hydroxylated form of hypoxia-inducible factors for degradation to orchestrate mammalian oxygen sensing. However, whether VHL plays non-canonical roles in hypoxia, when protein hydroxylation is attenuated, remains elusive. He...
ORGANISM(S): Homo sapiens (Human) 
2025-09-01 | PXD053354 | Pride
Hypoxia Mitochondrial Metabolism Vhl 
ProteomicsMitochondrial VHL rewires cell metabolism in hypoxia
Under normoxia, von Hippel-Lindau (VHL) protein targets the oxygen-induced, hydroxylated form of hypoxia-inducible factors for degradation to orchestrate mammalian oxygen sensing. However, whether VHL plays non-canonical roles in hypoxia, when protein hydroxylation is attenuated, remains elusive. He...
ORGANISM(S): Homo sapiens (Human) 
2025-08-26 | PXD056376 | Pride
Mitochondrial vhl hypoxia metabolism 
TranscriptomicsCellular and molecular characterization of the altered metabolism in RCC
RCC cells (786-O) were transfected with VHL. The parental cell line should be compared to the transfectant (+ VHL) under nomoxia as well as under hypoxia conditions. We want to distinct the VHL-mediated gene expression from the hypoxia-mediated and study the influence of both on the cellular metabol...
ORGANISM(S): Homo sapiens 
2015-01-22 | E-GEOD-65168 | biostudies-arrayexpress
ProteomicsHs_VHL
Proteomic analysis of signaling network regulation in renal cell carcinomas
ORGANISM(S): Homo Sapiens (human) 
2013-12-31 | PAe005018 | PeptideAtlas
UnknownVHL-Mediated Regulation of CHCHD4 and Mitochondrial Function.
Not available
S-EPMC6180203 | biostudies-literature
UnknownZNF395 Is a Hypoxia-Responsive Regulator of Mitochondrial Glutaminolysis in Clear Cell Renal Cell Carcinoma.
Not available
S-EPMC12875648 | biostudies-literature
UnknownUnique expression of the atypical mitochondrial subunit NDUFA4L2 in cerebral pericytes fine tunes HIF activity in response to hypoxia.
Not available
S-EPMC9875353 | biostudies-literature
UnknownImpaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome.
Not available
S-EPMC9236906 | biostudies-literature
UnknownCircadian Clock Interaction with HIF1α Mediates Oxygenic Metabolism and Anaerobic Glycolysis in Skeletal Muscle.
Not available
S-EPMC5226863 | biostudies-literature
UnknownSuppression of mitochondrial oxygen metabolism mediated by the transcription factor HIF-1 alleviates propofol-induced cell toxicity.
Not available
S-EPMC5997661 | biostudies-literature
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