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TranscriptomicsRNA-seq of a VHL-/- human renal cancer cell line 786-0 transfected with 3 vectors
The human renal cancer cell line 786-0 was transfected with 3 vectors allowing the doxycycline-inducible expression of 1) the full length wild type sequence of VHL: 786-0 VHL WT, VHL+/+, 2) the R167Q mutant : 786-0 R167Q, VHL mutated, 3) the empty vector : 786-0 EV, VHL-/-. The aim of the study was ...
ORGANISM(S): Homo sapiens 
2021-12-09 | E-MTAB-11168 | biostudies-arrayexpress
TranscriptomicsPleiotropic Effects of the Trichloroethylene-Associated P81S VHL Mutation on Metabolism, Apoptosis and ATM-Mediated DNA Damage Response
Gene expression data from VHL teratomas comparing genes differentially expressed based on apoptotic response to tumor microenvironment. Abstract BACKGROUND: The risk relevance of the P81S von Hippel-Lindau (VHL) gene hotspot mutation identified in clear cell renal cell carcinoma from individuals ex...
ORGANISM(S): Mus musculus 
2013-09-01 | E-GEOD-37464 | biostudies-arrayexpress
TranscriptomicsGene expression analysis in primary human renal tumors, categorized by VHL genotype and HIF-alpha expression
Human renal cell carcinomas (RCC) have differential expression of HIF-1alpha and HIF-2alpha, depending on VHL genotype and other events. Here, we have divided a series of RCC samples for HIF-alpha expression and VHL genotype, in order to define differentially expressed genes Keywords: Patient Sampl...
ORGANISM(S): Homo sapiens 
2008-12-27 | E-GEOD-11904 | biostudies-arrayexpress
TranscriptomicsArray CGH analysis in primary human renal tumors, categorized by VHL genotype and HIF-alpha expression
Human renal cell carcinomas (RCC) have differential expression of HIF-1alpha and HIF-2alpha, depending on VHL genotype and other events. Here, we have divided a series of RCC samples based on HIF-alpha expression, in order to examine levels of genomic DNA aberration. Keywords: Patient Sample Study ...
ORGANISM(S): Homo sapiens 
2008-12-27 | E-GEOD-13282 | biostudies-arrayexpress
TranscriptomicsCrosstalk between renal tumor suppressors: FLCN contributes to VHL tumor suppressing activity in renal cancer
Renal cancer accounts for 2% to 3% of all adult malignancies in the US. In 2011 more than 64,770 new cases and 13,000 deaths were reported and the incidence is steadily increasing by 2.5% per year. Clear cell renal carcinoma (ccRCC) represents the majority (85% to 90%) of adult kidney cancers and is...
ORGANISM(S): Homo sapiens 
2013-05-20 | E-GEOD-47106 | biostudies-arrayexpress
TranscriptomicsPatterns of gene expression and copy-number alterations in VHL disease-associated and sporadic ccRCC
Recent insights into the role of the VHL tumor suppressor gene in hereditary and sporadic clear cell carcinoma of the kidney (ccRCC) have led to new treatments for patients with metastatic ccRCC, although virtually all patients eventually succumb to the disease. We performed an integrated, genome-wi...
ORGANISM(S): Homo sapiens 
2010-04-10 | E-GEOD-14994 | biostudies-arrayexpress
TranscriptomicsIGR_VHL_GE
VHL is a tumor suppressor gene involved in the oxygen-sensing pathway whose germline mutations predispose to distinct phenotypes. Heterozygous mutations predispose to von Hippel-Lindau disease characterized by the development of multiple tumors (including hemangioblastomas, renal cell carcinomas and...
ORGANISM(S): Homo sapiens 
2013-09-03 | E-MTAB-1269 | biostudies-arrayexpress
TranscriptomicsVHL Status Influences Phenotype of Liver Cancers Arising from PTEN Loss
Background: PTEN loss contributes to the development of many cancers and is associated with both hepatocellular carcinoma and cholangiocarcinoma. The pathogenesis of these malignancies is unclear, but they are speculated to arise from common cellular origins. We explored the influence of secondary e...
ORGANISM(S): Mus musculus 
2014-10-31 | E-GEOD-55874 | biostudies-arrayexpress
TranscriptomicsSynthetic cystine addiction via programmed necrosis in VHL-deficient renal cell carcinoma
Altered metabolism is an important part of malignant transformation of tumor cells. Oncogenic transformation may reprogram tumor metabolism and render tumor cells addicted to extracellular nutrients. Such nutrient addictions associated with oncogenic mutations may offer therapeutic opportunities; ho...
ORGANISM(S): Homo sapiens 
2016-07-01 | E-GEOD-60422 | biostudies-arrayexpress
MetabolomicsMass Spectrometry-Based Metabolic Fingerprinting Contributes to Unveil the Role of RSUME in Renal Cell Carcinoma Cell Metabolism
Clear cell renal cell carcinoma (ccRCC) is a heterogeneous disease with 50-80% patients exhibiting mutations in the von Hippel-Lindau (VHL) gene. RSUME (RWD domain (termed after three major RWD-containing proteins: RING finger-containing proteins, WD-repeat-containing proteins, and yeast DEAD (DEXD)...
2021-10-06 | MTBLS1935 | MetaboLights
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