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ProteomicsDissecting the Roles of Mitochondrial Complex I Intermediate Assembly (MCIA) Complex Factors in the Biogenesis of Complex I
Mitochondrial Complex I harbors 7 mitochondrial and 38 nuclear-encoded subunits. Its biogenesis requires the assembly and integration of distinct intermediate modules, mediated by numerous assembly factors. The Mitochondrial Complex I Intermediate Assembly (MCIA) complex, containing assembly factors...
ORGANISM(S): Homo sapiens (Human) 
2020-04-22 | PXD018075 | Pride
Assembly factors Mitochondria Nadh-ubiquinone dehydrogenase Mcia complex Complex i Oxidative phosphorylation 
ProteomicsThe structural mechanism of MCIA complex assembly links mitochondrial redox pathways
The Mitochondrial Complex I Assembly (MCIA) complex is essential for the biogenesis of respiratory Complex I (CI), the first enzyme in the respiratory chain, which has been linked to Alzheimer’s disease (AD) pathogenesis. However, how MCIA facilitates CI assembly, and how it is linked with AD pathog...
ORGANISM(S): Escherichia coli 
2023-12-13 | PXD042858 | Pride
Oxidative phosphorylation (oxphos) Mitochondrial complex i assembly complex (mcia) Fatty acid oxidation (fao) Amyloid-β Ecsit phosphorylation Cryo-em 
ProteomicsThe assembly of the Mitochondrial Complex I Assembly complex uncovers a redox pathway coordination
The Mitochondrial Complex I Assembly (MCIA) complex is essential for the biogenesis of respiratory Complex I (CI), the first enzyme in the respiratory chain, which has been linked to Alzheimer’s disease (AD) pathogenesis. However, how MCIA facilitates CI assembly, and how it is linked with AD pathog...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2023-12-13 | PXD042905 | Pride
Keywords: oxidative phosphorylation (oxphos) Mitochondrial complex i assembly complex (mcia) Fatty acid oxidation (fao) Amyloid-β Ecsit phosphorylation Cryo-em 
ProteomicsSideroflexin 4 is a Complex I assembly factor that interacts with the MCIA complex and is required for the assembly of the ND2 module
Sideroflexins (SFXNs) comprise a family of five paralogous proteins (SFXN1-5) in metazoan species. SFXN1/2/3 function as serine transporters and are required for efficient mitochondrial one-carbon (1C) metabolism. SFXN4 is evolutionarily divergent and mutations in SFXN4 give rise to mitochondrial di...
ORGANISM(S): Homo sapiens (Human) 
2022-03-23 | PXD032762 | Pride
Human Mitochondria Sfxn4 
UnknownTIMMDC1/C3orf1 functions as a membrane-embedded mitochondrial complex I assembly factor through association with the MCIA complex.
Not available
S-EPMC4023825 | biostudies-literature
UnknownAssembly of The Mitochondrial Complex I Assembly Complex Suggests a Regulatory Role for Deflavination.
Not available
S-EPMC7986633 | biostudies-literature
UnknownThe assembly of the Mitochondrial Complex I Assembly complex uncovers a redox pathway coordination.
Not available
S-EPMC10716376 | biostudies-literature
UnknownTissue-specific differences in the assembly of mitochondrial Complex I are revealed by a novel ENU mutation in ECSIT.
Not available
S-EPMC10578914 | biostudies-literature
UnknownTMEM70 and TMEM242 help to assemble the rotor ring of human ATP synthase and interact with assembly factors for complex I.
Not available
S-EPMC8020751 | biostudies-literature
UnknownSideroflexin 4 is a complex I assembly factor that interacts with the MCIA complex and is required for the assembly of the ND2 module.
Not available
S-EPMC9060475 | biostudies-literature
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