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ProteomicsSideroflexin 4 is a Complex I assembly factor that interacts with the MCIA complex and is required for the assembly of the ND2 module
Sideroflexins (SFXNs) comprise a family of five paralogous proteins (SFXN1-5) in metazoan species. SFXN1/2/3 function as serine transporters and are required for efficient mitochondrial one-carbon (1C) metabolism. SFXN4 is evolutionarily divergent and mutations in SFXN4 give rise to mitochondrial di...
ORGANISM(S): Homo sapiens (Human) 
2022-03-23 | PXD032762 | Pride
Human Mitochondria Sfxn4 
UnknownComprehensive Analysis of Sideroflexin 4 in Hepatocellular Carcinoma by Bioinformatics and Experiments.
Not available
S-EPMC10542026 | biostudies-literature
UnknownMacrocytic anemia and mitochondriopathy resulting from a defect in sideroflexin 4.
Not available
S-EPMC3824126 | biostudies-literature
UnknownComplementary anti-cancer pathways triggered by inhibition of sideroflexin 4 in ovarian cancer.
Not available
S-EPMC9675821 | biostudies-literature
UnknownSideroflexin 4 affects Fe-S cluster biogenesis, iron metabolism, mitochondrial respiration and heme biosynthetic enzymes.
Not available
S-EPMC6928202 | biostudies-literature
UnknownSideroflexin 4 is a complex I assembly factor that interacts with the MCIA complex and is required for the assembly of the ND2 module.
Not available
S-EPMC9060475 | biostudies-literature
UnknownExploring the novel duo of Reticulocalbin, and Sideroflexin as future biomarker candidates for Exacerbated Chronic Obstructive Pulmonary Disease.
Not available
S-EPMC10865594 | biostudies-literature
UnknownConstruction and validation of an oxidative phosphorylation-related gene signature in lung squamous cell carcinoma patients.
Not available
S-EPMC12688223 | biostudies-literature
UnknownDynamic changes in lactate-related genes in microglia and their role in immune cell interactions after ischemic stroke.
Not available
S-EPMC12032981 | biostudies-literature
UnknownMulti-omics integrative analysis reveals novel genetic loci and candidate genes for ischemic stroke.
Not available
S-EPMC12328896 | biostudies-literature
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