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TranscriptomicsIntrauterine growth restriction is associated with cardiac ultrastructural and gene expression changes related to the energetic metabolism in a rabbit model
Intrauterine growth restriction (IUGR) affects 7-10% of pregnancies and is associated with cardiovascular remodeling and dysfunction which persists into adulthood. The underlying subcellular remodeling and cardiovascular programming events are still poorly documented. Cardiac muscle is central in th...
ORGANISM(S): Oryctolagus cuniculus 
2013-10-30 | E-GEOD-37860 | biostudies-arrayexpress
GenomicsMitochondrial energetic stress triggers AMPK/FNIP1-dependent TFEB nuclear translocation, inducing transcriptional waves of lysosomal and mitochondrial biogenesis.
Mitochondrial energetic stress triggers AMPK/FNIP1-dependent TFEB nuclear translocation, inducing transcriptional waves of lysosomal and mitochondrial biogenesis.
PRJNA905815 | ENA
ProteomicsInteractome quantitation reveals non-energetic mitochondrial roles in cell type specialization in murine kidney
Evolution of multicellular life forms has involved adaptation of organs that consist of multiple cell types, each with unique functional properties that as a collection, achieve complex organ function. Since each cell type is adapted to deliver specific functionality within the context of an organ,...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-29 | PXD062838 | Pride
Dia Mouse Kidney Xl-ms Mitochondria 
ProteomicsInteractome quantitation reveals non-energetic mitochondrial roles in cell type specialization in murine kidney
Evolution of multicellular life forms has involved adaptation of organs that consist of multiple cell types, each with unique functional properties that as a collection, achieve complex organ function. Since each cell type is adapted to deliver specific functionality within the context of an organ,...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-29 | PXD062841 | Pride
Mouse Kidney Xl-ms Mitochondria 
TranscriptomicsMitochondrial energetic stress triggers AMPK/FNIP1-dependent TFEB nuclear translocation, inducing transcriptional waves of lysosomal and mitochondrial biogenesis.
Cells respond to mitochondrial energetic stress with rapid activation of the AMP-activated protein kinase (AMPK), which acutely inhibits anabolism and stimulates catabolism. AMPK also induces sustained transcriptional reprogramming of metabolism. The TFEB transcription factor is a major effector of ...
ORGANISM(S): Homo sapiens 
2023-05-08 | GSE218827 | GEO
ProteomicsMitochondrial content normalization using mass spectrometry allows quantitative evaluation of intrinsic bioenergetic efficiency and the underlying proteome across mouse organs.
To separate global changes to metabolism from intrinsic mitochondrial remodeling, investigators commonly use isolated mitochondrial preparations obtained through differential centrifugation. This simple process has been reliably implemented in a variety of tissues to produce intact, functional mitoc...
ORGANISM(S): Mus Musculus (mouse) 
2021-07-09 | PXD020280 | JPOST Repository
ProteomicsInteractome quantitation reveals non-energetic mitochondrial roles in cell type specialization in murine kidney
Evolution of multicellular life forms has involved adaptation of organs that consist of multiple cell types, each with unique functional properties that as a collection, achieve complex organ function. Since each cell type is adapted to deliver specific functionality within the context of an organ,...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-29 | PXD062836 | Pride
Dia Mouse Kidney Xl-ms Mitochondria 
ProteomicsMitochondrial energetic failure underlies FLVCR1-related sensory neuropathy
Genetic pain loss disorders represent a heterogeneous group of rare diseases mainly characterized by defective nociception. Understanding the underlying molecular mechanism is fundamental to improve the treatment of patients affected by these rare disorders. Feline Leukemia Virus Subgroup C Receptor...
ORGANISM(S): Homo sapiens (Human) 
2026-02-02 | PXD071580 | Pride
Posterior column ataxia and retinitis pigmentosa  pcarp  retinitis pigmentosa  hereditary sensory and autonomic neuropathy  hsan  heme  choline  mams  mercs 
UnknownEnergetic costs of cellular and therapeutic control of stochastic mitochondrial DNA populations.
Not available
S-EPMC6615642 | biostudies-literature
TranscriptomicsEnhanced energetic state and protection from oxidative stress in human myoblasts overexpressing BMI1
The Polycomb group gene BMI1 is essential for efficient muscle regeneration in a mouse model of Duchenne Muscular Dystrophy and its enhanced expression in adult skeletal muscle satellite cells ameliorates the muscle strength in this model. In this experiment, we investigated the impact of mild BMI1 ...
ORGANISM(S): Homo sapiens 
2017-12-15 | E-MTAB-5846 | biostudies-arrayexpress
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