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MetabolomicsMuscle metabolic resilience and enhanced exercise adaptation by Esr1-induced remodeling of mitochondrial cristae-nucleoid architecture in males

Reduced estrogen action is associated with obesity and insulin resistance. However, the cell and tissue-specific actions of estradiol in maintaining metabolic health remain inadequately understood, especially in men. We observed that skeletal muscle ESR1/Esr1 (encodes estrogen receptor α) is posi...

2025-04-09 | MTBLS914 | MetaboLights
ProteomicsBrain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons
Supporting TMT MS data for paper (doi: 10.1016/j.neuron.2021.12.029) by Goldsmith J. et al., titled "Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons". Index of RAW files uploaded: AO3068-3079: Fractionated (12 fr...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-08-01 | MSV000092565 | MassIVE
MetabolomicsMitochondrial respiration in B lymphocytes is essential for humoral immunity by controlling flux of the TCA cycle

To elucidate the function of oxidative phosphorylation (OxPhos) during B-cell differentiation we employ CD23Cre-driven expression of the dominant-negative K320E mutant of the mitochondrial helicase Twinkle (DNT). DNT-expression depletes mitochondrial DNA during B cell maturation, reduces the abun...

2026-08-21 | MTBLS4647 | MetaboLights
GenomicsSingle-nucleoid architecture reveals heterogeneous packaging of mitochondrial DNA
Single-nucleoid architecture reveals heterogeneous packaging of mitochondrial DNA
PRJNA876259 | ENA
UnknownMitochondrial nucleoid interacting proteins support mitochondrial protein synthesis.
Not available
S-EPMC3401451 | biostudies-literature
UnknownmtFociCounter for automated single-cell mitochondrial nucleoid quantification and reproducible foci analysis.
Not available
S-EPMC10681798 | biostudies-literature
GenomicsSingle-nucleoid architecture reveals heterogeneous packaging of mitochondrial DNA
Single-nucleoid architecture reveals heterogeneous packaging of mitochondrial DNA
PRJNA876258 | ENA
UnknownPossible frequent multiple mitochondrial DNA copies in a single nucleoid in HeLa cells.
Not available
S-EPMC10082775 | biostudies-literature
UnknownHuman C4orf14 interacts with the mitochondrial nucleoid and is involved in the biogenesis of the small mitochondrial ribosomal subunit.
Not available
S-EPMC3401442 | biostudies-literature
ProteomicsNucleoid-Enriched Proteomes in Developing Plastids and Chloroplasts from Maize Leaves: A New Conceptual Framework for Nucleoid Functions
Plastids contain multiple copies of the plastid chromosome, folded together with proteins and RNA into nucleoids. The degree to which components of the plastid gene expression and protein biogenesis machineries are nucleoid associated, and the factors involved in plastid DNA organization, repair, an...
ORGANISM(S): Zea mays (Maize) 
2023-09-28 | PXD045331 | Pride
Proplastids Nucleoids Maize Leaf development Chloroplasts 
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