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MetabolomicsMYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with Host Cell Factor-1
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ORGANISM(S): Homo sapiens 
ST001429 | MetabolomicsWorkbench
MetabolomicsA Generalized Strategy to Kill Leukemic Cells by Targeting the Regulatory Systems Governing Mitochondrial Membrane Potential
Targeting mitochondria emerges as a promising anti-leukemia strategy, yet selective mitochondrial disruption remains challenging. Here, we identified elevated mitochondrial membrane potential (MMP) as a hallmark of leukemic transformation and chemotherapy-resistant cells, prompting screening for MMP...
2025-07-11 | MTBLS12596 | MetaboLights
TranscriptomicsRibosome profiling reveals features of normal and disease-associated mitochondrial translation
Ribosome profiling and RNAseq data on human BJ fibroblasts and cybrid cells using an adapted ribosome profiling protocol to improve detection of mitochondrial ribosome protected fragments 51-base length single read ribosome profiling data on human fibroblasts and cybrid cells using an adapted riboso...
ORGANISM(S): Homo sapiens 
2013-10-17 | E-GEOD-48933 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human 293T cell line mitochondrial small RNA transcriptome
This study aimed to determine whether human nuclear-encoded tRNAs can enter mitochondria and to assess their potential involvement in mitochondrial protein translation. We isolated cytoplasmic fractions, intact mitochondria, and mitoplasts from human HEK293T cells and performed small RNA sequencing ...
ORGANISM(S): Homo sapiens 
2026-08-27 | E-MTAB-15948 | biostudies-arrayexpress
TranscriptomicsAnalysis of mitochondrial gene expression with Ribosome Profiling
Ribosome profiling (RiboSeq) maps positions of translating ribosomes on the transcriptome. Here we optimized ribosome profiling for footprinting mitochondrial ribosomes, and profiled three human cell-lines - HEK293, a PDE12-/- knockout, and a deltaFLP 143B cybrid.
ORGANISM(S): Homo sapiens 
2017-07-25 | E-MTAB-5519 | biostudies-arrayexpress
TranscriptomicsCardiac mitochondrial function depends on BUD23 mediated ribosome programming
Efficient mitochondrial function is required in tissues with high energy demand such as the heart, and mitochondrial dysfunction is associated with cardiovascular disease. Expression of mitochondrial proteins is tightly regulated in response to internal and external stimuli. Here we identify a novel...
ORGANISM(S): Homo sapiens 
2020-01-23 | E-MTAB-8673 | biostudies-arrayexpress
MetabolomicsRibosomal mistranslation leads to silencing of the unfolded protein response and increased mitochondrial biogenesis

Translation fidelity is the limiting factor in the accuracy of gene expression. With an estimated frequency of 10-4, errors in mRNA decoding occur in a mostly stochastic manner. Little is known about the response of higher eukaryotes to chronic loss of ribosomal accuracy as per an increase in the...

2019-09-17 | MTBLS106 | MetaboLights
TranscriptomicsTime resolved ribosome profiling study of oxygen and glucose deprivation of rat pheochromocytoma cells
Oxygen and glucose metabolism plays a pivotal role in many (patho)physiological conditions. In particular, oxygen and glucose deprivation (OGD) occurs during ischemia and stroke, resulting in extensive tissue injury and cell death. We applied time-resolved ribosome profiling technique to assess earl...
ORGANISM(S): Rattus norvegicus 
2015-04-10 | E-GEOD-60752 | biostudies-arrayexpress
MetabolomicsCommon Metabolic Pathways Implicated in Resistance to Chemotherapy Point to a Key Mitochondrial Role in Breast Cancer
Cancer cells are known to reprogram their metabolism to adapt to adverse conditions dictated by tumor growth and microenvironment. A subtype of cancer cells with stem-like properties, known as cancer stem cells (CSC), is thought to be responsible for tumor recurrence. In this study, we demonstrated ...
2019-08-19 | MTBLS678 | MetaboLights
TranscriptomicsLooking for mitochondrial associated RNA
We investigated the peripheral mitochondrial localization of nuclear-encoded mRNAs (MLR) in various conditions in which translation was inhibited or the mRNA binding protein context altered (Delta puf3). We used cell fractionation protocols together with microarray to assess the distribution of mRNA...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-01 | E-GEOD-9393 | biostudies-arrayexpress
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