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MetabolomicsStress-related mitogen-activated protein kinases stimulate the accumulation of small molecules and proteins in Arabidopsis thaliana root exudates
A delicate balance in cellular signaling is required for plants to distinguish mutualist from parasitic organisms in its environment. Mitogen-activated protein kinase (MAPK) cascades are one of the signaling modules that mediate transduction of extracellular microbial signals into appropriate cellul...
2017-08-25 | MTBLS441 | MetaboLights
TranscriptomicsDifferential Regulation of Mitogen-Activated Protein Kinases by Acetaminophen in TAMH cells
Acetaminophen (APAP), a widely used analgesic and antipyretic that is considered to be relatively safe at recommended doses, is the leading cause of drug-induced liver failure in the United States. 3M-bM-^@M-^Y-Hydroxyacetanilide (AMAP), a regioisomer of acetaminophen is useful as a comparative too...
ORGANISM(S): Mus musculus 
2010-07-06 | E-GEOD-18614 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of left ventricle tissues from rat with overexpression of constitutively active upstream kinase mitogen-activated protein kinase kinase 3b (MKK3bE) and wild-type p38? in the heart
Mitogen-activated protein kinases (MAPKs) regulate cardiomyocyte growth and apoptosis in response to extracellular stimulation, but the downstream effectors that mediate their pathophysiological effects remain poorly understood. We determined the targets and role of p38 MAPK in the heart in vivo by ...
ORGANISM(S): Rattus norvegicus 
2009-04-25 | E-GEOD-3866 | biostudies-arrayexpress
ProteomicsIdentification of Mitogen-Activated Protein Kinase Phosphatase-1 (MKP-1) protein partners using Tandem Affinity Purification and Mass Spectrometry
According to the World Health Organization Report, depressive disorders affect about 10% of the population. The molecular mechanism of the pathogenesis of depression is still not well understood. The new findings point to phosphatases as potential targets for effective depression therapy. The aim of...
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2023-01-19 | MSV000091093 | MassIVE
TranscriptomicsChromatin immunoprecipitation of activated yeast signal transduction protein kinases
Cellular signal transduction pathways modify gene expression programs in response to changes in the environment, but the mechanisms by which they regulate populations of genes under their control are not entirely understood. We present evidence that most mitogen-activated protein kinases and protei...
ORGANISM(S): Saccharomyces cerevisiae 
2006-07-28 | E-TABM-98 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis mkk1, mkk2 and mkk1/2 knockout treated with the saliicylic acid analog BTH
Gene Expression profiling of the Arabidopsis thaliana MAP Kinase Kinases 1 (mkk1), MAP Kinase Kinases 2 (mkk2) knockout mutants and the double mutant mkk1/mkk2 before and 24 hours after treatment with the salicylic acid analog BTH, was measured by hybridisation to an Affymetrix ATH1 GeneChip. Experi...
ORGANISM(S): Arabidopsis thaliana 
2008-06-11 | E-GEOD-10646 | biostudies-arrayexpress
TranscriptomicsExpression analysis of Arabidopsis mpk11 mutant treated with flg22
Arabidopsis MPK11 is activated and plays a role in the flg22 sensing. Mitogen-activated protein kinases (MAPKs) mediate cellular signal transduction during stress responses, as well as diverse growth and developmental steps in eukaryotes. Pathogen infection or treatment with conserved pathogen-assoc...
ORGANISM(S): Arabidopsis thaliana 
2012-05-02 | E-GEOD-33648 | biostudies-arrayexpress
GenomicsLinear motif specificity in signaling through p38α and ERK2 mitogen–activated protein kinases
Linear motif specificity in signaling through p38α and ERK2 mitogen–activated protein kinases
PRJNA1208945 | ENA
no omics definedTranscription profiling by array of mouse motor nerve-stimulated and the contralateral control tabialis anterior muscles
Exercise induces skeletal muscle adaptation, and the p38 mitogen-activated protein kinase signaling pathway is thought to play an important role in the adaptive processes. We have obtained new evidence that the gamma isoform of p38 is required for exercise-induced metabolic adaptation in skeletal mu...
ORGANISM(S): Mus musculus 
2010-03-03 | E-GEOD-17620 | biostudies-arrayexpress
Genomics
Soybean Mitogen Activated protein Kinases (MAPKs)
PRJNA664992 | ENA
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