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Mitomycin C is a DNA crosslinking agent. This experiment was carried out to determine the effect of Mitomycin C on genome wide transcription in Streptomyces venezuelae NRRL B65442.
ORGANISM(S): Streptomyces venezuelae 
The SOS response is a conserved pathway that is activated under certain stress conditions and is regulated by the repressor LexA and the activator RecA. The food-borne pathogen Listeria monocytogenes contains RecA and LexA homologs, but their roles in Listeria have not been established. In this stud...
ORGANISM(S): Listeria monocytogenes EGD-e 
Genotoxic stress in mammalian cells defined as a situation that initiates DNA damage compromising the cell’s genomic integrity leading to replication and transcription arrest underlies many pathological conditions including cellular senescence, cancer and cardiovascular diseases. Recent experimental...
ORGANISM(S): Homo sapiens (Human) 
2024-06-22 | PXD050743 | Pride
Molecular basis of mitomycin C enhanced corneal sensory nerve repair
Transcriptional profiling of A. baumannii ATCC 17978 comparing treated-MMC cultures with non-MMC treated cultures Two-condition experiment A. baumannii 17978 MMC+ vs A. baumannii 17978 MMC-. Biological replicates:3, Technical replicates:2
ORGANISM(S): Acinetobacter baumannii ATCC 17978 
Mouse lymphoma L5178Y cells are treated with Mitomycin C [CAS:50-07-7;CHEBI:27504] and harvested at 4 and 24 hours for analysis.
ORGANISM(S): Mus musculus 
Genome-wide screen unveils the synthetic lethality targets of mitomycin C
Transcriptional response of Prochlorococcus strain MIT0604 to mitomycin C and UV stress
RNA-Seq of Streptomyces venezuelae grown overnight (14 hrs) with Mitomycin-C against untreated controls.
Mitomycin C (MC) is an anti-cancer drug which functions by forming interstrand crosslinks between opposing DNA strands. MC analog, 10-decarbamoyl mitomycin C (DMC), unlike MC, has stronger cytotoxic effects on cancer with TP53 mutation. We previously demonstrated that MC/DMC could activate p21WAF1/C...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-04-21 | MSV000094585 | MassIVE
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