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ProteomicsKu80 interaction proteins under enhanced mitophagy
We reported Ku80 as a critical mitophagy protein and closely related to chemotherapy efficacy in liver cancer. The project detects the Ku80-interacted proteins under the condition of mitophagy activator or exogenously overexpression of Ku80 gene. After immunoprecipitation pulldown via anti-Ku80 or ...
ORGANISM(S): Homo sapiens (Human) 
2026-05-14 | PXD062704 | Pride
Ku80 Mitophagy activator Liver cancer 
ProteomicsPutative PINK1/Parkin activators cause mitochondrial stress and lower the threshold for mitophagy
The PINK1/Parkin pathway is responsible for targeting damaged mitochondria for degradation via mitophagy. Because genetic evidence links impaired mitophagy to Parkinson’s disease, pharmacologic enhancement of mitophagy represents a promising disease-modifying strategy. Here, we characterize two phar...
ORGANISM(S): Homo sapiens (Human) 
2025-06-03 | PXD058150 | Pride
Mitochondria  mitophagy Autophagy  pink1/parkin pathway  mitochondrial stress  neurodegeneration  parkinson’s disease  integrated stress response (isr)  drug discovery  off-target toxicity. 
UnknownA novel small-molecule activator of Sirtuin-1 induces autophagic cell death/mitophagy as a potential therapeutic strategy in glioblastoma.
Not available
S-EPMC6039470 | biostudies-literature
GenomicsAdipose TET proteins suppress browning and energy expenditure by epigenetic suppression of Parkin-mediated mitophagy
Adipose TET proteins suppress browning and energy expenditure by epigenetic suppression of Parkin-mediated mitophagy
PRJNA1148624 | ENA
TranscriptomicsAdipose TET proteins suppress browning and energy expenditure by epigenetic suppression of Parkin-mediated mitophagy
Parkin, an E3 ubiquitin ligase, is necessary for mitophagy. Parkin-mediated mitophagy is down-regulated in thermogenic activation including WAT browning and BAT activation, but the molecular mechanism of Parkin regulating remains poorly understood. Ten-eleven translocation (TET) proteins catalyze th...
ORGANISM(S): Mus musculus 
2026-08-31 | GSE274950 | GEO
UnknownPutative PINK1/Parkin activators lower the threshold for mitophagy by sensitizing cells to mitochondrial stress.
Not available
S-EPMC12383277 | biostudies-literature
UnknownCirsiliol regulates mitophagy in colon cancer cells via STAT3 signaling.
Not available
S-EPMC9541001 | biostudies-literature
UnknownUrolithin A attenuates auditory cell senescence by activating mitophagy.
Not available
S-EPMC9095590 | biostudies-literature
UnknownActivation of mitophagy antagonizes high uric acid-induced hepatic lipid accumulation.
Not available
S-EPMC12805366 | biostudies-literature
UnknownIncreased mitophagy protects cochlear hair cells from aminoglycoside-induced damage.
Not available
S-EPMC9809934 | biostudies-literature
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