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TranscriptomicsSingle cell sequencing of developing heart valves identifies novel cell populations and uncovers interstitial cell heterogeneity
This study has two main goals. The first is to define a gene expression atlas of heart valve cells and identify cell heterogeneity within postnatal heart valve development. The second is to identify interstitial cell populations involved in ECM remodeling during postnatal heart valve development. Ov...
ORGANISM(S): Mus musculus 
2018-07-13 | E-HCAD-18 | biostudies-arrayexpress
ProteomicsIntegration of functional imaging, cytometry and unbiased proteomics reveals new features of endothelial-to-mesenchymal transition in ischemic mitral valve regurgitation in human patients
Background: Following myocardial infarction, mitral regurgitation (MR) is a common complication. Previous animal studies demonstrated the association of endothelial-to-mesenchymal transition (EndMT) with mitral valve (MV) remodeling. Nevertheless, little is known about how MV tissue responds to isch...
ORGANISM(S): Homo sapiens (Human) 
2021-08-13 | PXD025096 | Pride
Human Mitral valve (mv) Proteomic Ischemic mitral regurgitation (imr) Echocardiography Endothelial-to-mesenchymal transition (endmt) Histo-cytometry 
TranscriptomicsThe gene expression profiles associated with worsening left ventricle function after mitral valve repair
Background:To assess left ventricular (LV) transcriptome determinants of worsening LV function after mitral valve (MV) repair. Results:Upregulated protein ubiquitination-related genes associated with worsening-LVF after MV repair may likely exert its adverse effect in left ventricle through increase...
ORGANISM(S): Homo sapiens 
2020-08-12 | GSE150661 | GEO
GenomicsThe Wnt inhibitor sFRP3 protects mitral valve endothelium from MI-induced EndMT
The Wnt inhibitor sFRP3 protects mitral valve endothelium from MI-induced EndMT
PRJNA757436 | ENA
GenomicsThe gene expression profiles associated with worsening left ventricle function after mitral valve repair
The gene expression profiles associated with worsening left ventricle function after mitral valve repair
PRJNA633114 | ENA
GenomicsMitral valve leaflet response to ischemic mitral regurgitation: From gene expression to tissue remodeling
Mitral valve leaflet response to ischemic mitral regurgitation: From gene expression to tissue remodeling
PRJNA587626 | ENA
TranscriptomicsThe Wnt inhibitor sFRP3 protects mitral valve endothelium from MI-induced EndMT
Rational: We previously reported evidence of endothelial to mesenchymal transition (EndMT) and fibrosis in mitral valve (MV) leaflets at two to six months post-myocardial infarction (MI) in sheep. The onset of these changes and the mechanism of their instigation are not known. Early modulation of En...
ORGANISM(S): Ovis aries 
2022-01-15 | GSE182696 | GEO
GenomicsMitral valve interstitial Tissue: Myxomatous P2 prolapse of the mitral valve vs. Control
Mitral valve interstitial Tissue: Myxomatous P2 prolapse of the mitral valve vs. Control
PRJNA431911 | ENA
TranscriptomicsTranscriptomic profiling study of canine degenerative mitral valve disease
Degenerative mitral valve disease (DMVD) is the most common cardiac disease in dogs. Some signaling pathways have been implicated in DMVD, including the serotonin and TGF-beta pathways. We sought to identify additional molecular and metabolic pathways that contribute to DMVD using transcriptomic and...
ORGANISM(S): Canis lupus familiaris 
2015-05-29 | GSE64544 | GEO
TranscriptomicsMitral valve leaflet response to ischemic mitral regurgitation: From gene expression to tissue remodeling
Rationale: Ischemic mitral regurgitation (IMR) is frequently observed following myocardial infarction (MI) and is associated with higher mortality and poor clinical prognosis if left untreated. Accumulating evidence suggests that mitral valve (MV) leaflets actively remodel post-MI, yet the cellular ...
ORGANISM(S): Ovis aries 
2020-05-06 | GSE139921 | GEO
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