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ProteomicsA non-hazardous deparaffinization protocol enables quantita-tive proteomics of core needle biopsy-sized formalin-fixed and paraffin embedded (FFPE) tissue specimens.
Most human tumor tissues that are obtained for pathology and diagnostic purposes are forma-lin-fixed and paraffin embedded (FFPE). To perform quantitative proteomics of FFPE samples, paraffin has to be removed and formalin-induced crosslinks have to be reversed prior to prote-olytic digestion. A c...
ORGANISM(S): Homo sapiens (Human) 
2022-05-19 | PXD031946 | Pride
Clinical proteomics  tumor tissues  ffpe  quantitative proteomics  core needle biopsy  cancer research  molecular pathology  breast ductal carcinoma  in-situ cancer 
ProteomicsClinical proteomics reveals vulnerabilities in non-invasive breast ductal carcinoma and drives personalized treatment strategies
Ductal carcinoma in situ (DCIS) is the most common type (80%) of non-invasive breast lesions in women. The lack of validated prognostic markers, limited patient numbers, and variable tissue quality have a significant impact on diagnosis, risk stratification, patient enrolment, and the results of cli...
ORGANISM(S): Homo sapiens (Human) 
2024-12-31 | PXD040782 | Pride
Multi-omics Clinical proteomics Cancer research Biomarker 
ProteomicsEstablishing personalized blood protein reference ranges using non-invasive microsampling and targeted proteomics: Implications for anti-doping strategies
To prevent doping practices in sports, the World Anti-Doping Agency implemented the Athlete Biological Passport (ABP) program, monitoring biological variables over time to indirectly reveal effects of doping rather than detect the doping substance or method itself. In the context of this program an...
ORGANISM(S): Homo Sapiens 
PXD048168 | panorama
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