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TranscriptomicsGene expression profiles of myeloma cells treated with NAE inhibitor
The transcriptional profile of the human multiple myeloma (MM) cell line MM.1S treated with MLN4924 vs control MM.1S cells was characterized by oligonucleotide microarray analysis, using the human U133 plus 2.0 Affymetrix GeneChip, according to previously described protocols for total RNA extraction...
ORGANISM(S): Homo sapiens 
2012-05-01 | E-GEOD-33577 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human multiple myeloma cells co-cultured with bone marrow stromal cells in vitro
Conventional anti-cancer drug screening is typically performed in the absence of accessory cells (e.g. stromal cells) of the tumor microenvironment, which can profoundly alter anti-tumor drug activity. To address this major limitation, we have developed assays (e.g. the tumor cell-specific in vitro ...
ORGANISM(S): Homo sapiens 
2010-03-23 | E-GEOD-20540 | biostudies-arrayexpress
TranscriptomicsIdentification of differentially expressed genes upon treatment with Eltrombopag in HL60 cells
Identification of differentially expressed genes upon treatment with Eltrombopag in HL60 cells. HL60 cells were untreated, or treated with 3ug/ml of Eltrombopag for 36 hrs in RPMI with 10% FBS HL60 cells were untreated, or treated with 3ug/ml of Eltrombopag for 36 hrs in RPMI with 10% FBS
ORGANISM(S): Homo sapiens 
2012-06-24 | E-GEOD-37580 | biostudies-arrayexpress
TranscriptomicsIdentification of differentially regulated genes upon overexpression of HLX in wild-type hematopoietic stem cells
The goal was to study the role of Hlx in hematopoiesis. Sorted Lin-Kit+Sca-1+ cells from wild-type FVB/nJ bone marrow were infected with control (pCAD-IRES-GFP) or Hlx lentivirus (pCAD-IRES-GFP-Hlx) and cultured for 2 days in Iscove’s modified Dulbecco’s medium (IMDM) containing FBS, mIL-3, mIL-6 an...
ORGANISM(S): Mus musculus 
2012-09-14 | E-GEOD-27938 | biostudies-arrayexpress
TranscriptomicsIdentification of differentially regulated genes upon shRNA-mediated knock-down of HLX in the URE leukemia cell line
To study the role of Hlx in hematopoietic differentiation and tumorigenesis, URE cells were infected with short-hairpin-containing pSIH1-H1-copGFP lentiviral vector (System Biosciences, Mountain View, CA) containing either nucleotide sequences targeting luciferase (shControl) or HLX (shHLX). After 2...
ORGANISM(S): Mus musculus 
2012-09-14 | E-GEOD-27939 | biostudies-arrayexpress
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