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TranscriptomicsmiRNA expression signatures in Tif1b-deficient hematopoietic stem cell
miRNA expression analyses of Tif1b-deficient hematopoietic stem cells (HSCs). Tif1b loss leds to rapid depletion of HSCs. Expression analyses provide insight into the role of Tif1b in the maitenance of HSC. HSCs (c-Kit+ Sca1+ Lineage- ) are sorted from adult bone marrow and are subjected into micr...
ORGANISM(S): Mus musculus 
2013-11-12 | E-GEOD-52282 | biostudies-arrayexpress
TranscriptomicsExpression data from Ezh2-null erythrocyte/megakaryocyte progenitor (MEP)
The polycomb group (PcG) proteins function in gene silencing through histone modifications. They form chromatin-associated multiprotein complexes, termed polycomb repressive complex (PRC) 1 and PRC2. These two complexes work in a coordinated manner in the maintenance of cellular memories through tra...
ORGANISM(S): Mus musculus 
2011-12-27 | E-GEOD-32929 | biostudies-arrayexpress
TranscriptomicsCritical role of SOX17 in the hematopoietic development from human embryonic stem cells
Human embryonic stem cells (hESCs) are a powerful tool for modeling regenerative therapy. To search for the genes that promote hematopoietic development from human pluripotent stem cell, we overexpressed a list of hematopoietic regulator genes in human pluripotent stem cell-derived CD34+CD43- endoth...
ORGANISM(S): Homo sapiens 
2012-12-14 | E-GEOD-38156 | biostudies-arrayexpress
TranscriptomicsGene expression signatures in Tif1b-deficient hematopoietic stem cell
Gene expression analyses of Tif1b-deficient hematopoietic stem cells (HSCs). Tif1b loss leads to rapid depletion of HSCs. Expression analyses provide insight into the role of Tif1b in the maitenance of HSC. HSCs (c-Kit+ Sca1+ Lineage- ) are sorted from fetal liver or adult bone marrow and are subj...
ORGANISM(S): Mus musculus 
2013-11-06 | E-GEOD-48929 | biostudies-arrayexpress
TranscriptomicsGene expression changes during hematopoietic cell differentiation
Gene expression analyses of hematopoietic stem cells (HSCs), progenitor cells (HPCs), and differentiated cell. Gene expressions of long-term HSCs (CD34-ckit+Sca1+Lineage-), short term HSCs (CD34+ckit+Sca1+Lineage-), Progenitor cells (ckit+Sca1- Lineage-), and differentiated cels (Lineage+) were ex...
ORGANISM(S): Mus musculus 
2013-11-06 | E-GEOD-48986 | biostudies-arrayexpress
TranscriptomicsChIP-on-chip data from human ES cells-derived CD34+CD43+CD45low cells (hemogenic endothelium-like cells) overexpressing 3xFLAG-Sox17-ERT
Overexpression of transcription factor Sox17 in human ES cells-derived endothelial cells enhances expansion of hemogenic endothelium-like cells. Human ES cells were differentiated for 6 days in EBs, then CD34+CD43-CD45- endothelial cells were isolated, plated onto OP9 cells, and transduced with the ...
ORGANISM(S): Homo sapiens 
2012-12-14 | E-GEOD-37528 | biostudies-arrayexpress
TranscriptomicsExpression data of human ES cells-derived CD34+CD43+CD45low cells (hemogenic endothelium-like cells) expanded upon overexpression of Sox17
Overexpression of transcription factor Sox17 in human ES cells-derived endothelial cells and hematopoietic cells enhances expansion of hemogenic endothelium-like cells. Human ES cells were differentiated for 6 days, 8 days or 12 days in EBs, then CD34+CD43-CD45- endothelial cells, CD34+CD43+CD45- pr...
ORGANISM(S): Homo sapiens 
2012-12-14 | E-GEOD-37348 | biostudies-arrayexpress
TranscriptomicsGene expression signatures in Tif1b, Hp1a or Hp1g knockdown hematopoietic progenitors
Gene expression analyses of Tif1b, Hp1a or Hp1g knockdown hematopoietic progenitors. Growth of hematopoietic stem cells (HSCs) are significantly impaired upon knockdown of Hp1a and Hp1g. Results provide insight into the role of these factors in hematopoiesis. HSCs (CD34- c-Kit+ Sca1+ Lineage- ) we...
ORGANISM(S): Mus musculus 
2014-08-01 | E-GEOD-48897 | biostudies-arrayexpress
TranscriptomicsExpression data of mouse developmental T cells (CD4CD8DP, CD4SP and CD8SP) derived from Brd1 deficient thymocyte
Conditional knock out of Brd1(bromodomain containing 1) in muse developmental T cells (CD4CD8DP, CD4SP and CD8SP) by intercrossing with Tie2-Cre Conditional knock out of Brd1(bromodomain containing 1) in muse MHC class l restricted T cells (CD8SP) by intercrossing with Tie2-Cre and OT-l Developmenta...
ORGANISM(S): Mus musculus 
2014-05-24 | E-GEOD-48797 | biostudies-arrayexpress
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Mouse NAMPT targeted therapy)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7252 | MetaboLights
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