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TranscriptomicsTranscription profiling of mouse intestinal epithelial spheroids cultured as stem cells, wound-associated epithelial cells or enterocytes
Intestinal epithelial spheroids were isolated from mouse jejunum as described in our previous publication (Miyoshi and Stappenbeck. In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture. Nature Protocols. 2013. PMID: 24232249) and then grown in 50% L-WRN cond...
ORGANISM(S): Mus musculus 
2016-10-25 | E-MTAB-3952 | biostudies-arrayexpress
TranscriptomicsMouse colonic crypt regeneration after tissue injury
Transcriptional profiling of microscopically laser dissected murine colonic tissue from 3 separate normal crypts, wound associated epithelium (WAE), normal epithelium, and regenerating crypts (day 6 only) at days 2,4,and 6 after colonic mucosal injury. Injury model performed as described in: H. Seno...
ORGANISM(S): Mus musculus 
2012-06-18 | E-MTAB-1175 | biostudies-arrayexpress
TranscriptomicsGene expression profile of mouse hematopoietic stem cells
Mouse CD34(-)KSL hematopoietic stem cells and CD34(+)KSL multipotent progenitors were purified by cell sorting from bone marrow of 8-week-old C57BL/6 mice, and their gene expression was analyzed. Two biological replicates of CD34(-)KSL hematopoietic stem cells and CD34(+)KSL multipotent progenitors ...
ORGANISM(S): Mus musculus 
2011-05-19 | E-GEOD-27785 | biostudies-arrayexpress
TranscriptomicsGene expression profile of mouse hematopoietic cells
Each fraction of mouse hematopoietic cells was purified by cell sorting from bone marrow of 8-week-old C57BL/6 mice, and its gene expression was analyzed. Two biological replicates of each fraction were analyzed using a Mouse Genome 430 2.0 array (Affymetrix).
ORGANISM(S): Mus musculus 
2011-05-19 | E-GEOD-27786 | biostudies-arrayexpress
TranscriptomicsIdentification of mir-342-3p functionally associated with transcriptional activity of MYC in lung cancer [cell culture]
Accumulating evidence indicates that altered miRNA expression is crucially involved in lung cancer development, but only little has been elucidated about how MYC, an archetypical oncogene, is regulated by miRNAs, especially through a mechanism involving the MYC cofactor(s). In this study, we aimed a...
ORGANISM(S): Homo sapiens 
2016-01-06 | E-GEOD-66758 | biostudies-arrayexpress
TranscriptomicsIdentification of mir-342-3p functionally associated with transcriptional activity of MYC in lung cancer [patients]
Accumulating evidence indicates that altered miRNA expression is crucially involved in lung cancer development, but only little has been elucidated about how MYC, an archetypical oncogene, is regulated by miRNAs, especially through a mechanism involving the MYC cofactor(s). In this study, we aimed a...
ORGANISM(S): Homo sapiens 
2016-01-06 | E-GEOD-66759 | biostudies-arrayexpress
TranscriptomicsBiallelic and complicated inactivation of Pten in radiation-induced mouse thymic lymphomas
Inactivation of Pten occurs by multiple mechanisms including epigenetic silencing, point mutations, insertion, and deletion, which are tissue dependent. Although frequent loss of heterozygosity around Pten locus and plausible involvement of epigenetic silencing have been reported in radiation-induce...
ORGANISM(S): Mus musculus 
2010-05-06 | E-GEOD-17751 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse hypomorphic for ATG16L1 (implicated in Crohns disease) protein expression reveals a key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
Susceptibility to Crohn's disease, a complex inflammatory disease involving the small intestine, is controlled by over 30 loci. One Crohn's disease risk allele is in ATG16L1, a gene homologous to the essential yeast autophagy gene ATG16 (ref. 2). It is not known how ATG16L1 or autophagy contributes ...
ORGANISM(S): Mus musculus 
2008-11-15 | E-GEOD-13512 | biostudies-arrayexpress
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