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TranscriptomicsMYBPH, a novel transcriptional target of NKX2-1/TTF-1, inhibits ROCK1 and actomyosin assembly, and reduces cell motility and tumor metastasis
Cell migration driven by actomyosin filament assembly is a critical step in tumour invasion and metastasis. Herein, we report identification of myosin binding protein H (MYBPH) as a transcriptional target of NKX2-1 (also known as TTF-1 and TITF1), a lineage-survival oncogene in lung adenocarcinoma. ...
ORGANISM(S): Homo sapiens 
2011-12-22 | E-GEOD-26721 | biostudies-arrayexpress
TranscriptomicsRNAi-mediated knockdown of Xist can rescue the impaired postimplantation development of cloned mouse embryo
Cloning mammals by somatic cell nuclear transfer (SCNT) is highly inefficient. Most SCNT-generated embryos die after implantation because of unidentified, complex epigenetic errors in the process of postimplantation embryonic development. Here, we identified the most upstream level of dysfunction le...
ORGANISM(S): Mus musculus 
2011-11-17 | E-GEOD-33208 | biostudies-arrayexpress
TranscriptomicsmiR-130a activates apoptotic signaling through activation of caspase-8 in taxane-resistant prostate cancer cells [total RNA]
Background: The acquisition of drug resistance is one of the most malignant phenotypes of cancer. MicroRNAs (miRNAs) have been implicated in various types of cancers, but its role in taxane-resistance of prostate cancer remains poorly understood. Methods: In order to identify miRNAs related to taxan...
ORGANISM(S): Homo sapiens 
2015-07-31 | E-GEOD-64012 | biostudies-arrayexpress
TranscriptomicsmiR-130a activates apoptotic signaling through activation of caspase-8 in taxane-resistant prostate cancer cells [miRNA]
Background: The acquisition of drug resistance is one of the most malignant phenotypes of cancer. MicroRNAs (miRNAs) have been implicated in various types of cancers, but its role in taxane-resistance of prostate cancer remains poorly understood. Methods: In order to identify miRNAs related to taxan...
ORGANISM(S): Homo sapiens 
2015-07-31 | E-GEOD-64013 | biostudies-arrayexpress
TranscriptomicsGenomic Reprogramming Errors Do Not Accumulate with Serial Recloning in the Mouse
To date, the success rate of serial animal cloning has decreased with increasing iterations and recloning has failed in all species after a few generations. This has suggested that recloning might be impossible because of the accumulation of lethal genetic or epigenetic abnormalities. Here, we carri...
ORGANISM(S): Mus musculus 
2013-01-15 | E-GEOD-43476 | biostudies-arrayexpress
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