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ProteomicsArchitecture of the MKK6-p38α complex defines the basis of MAPK specificity and activation
The MAP kinase p38α is a central component of signalling in inflammation and the immune response, and is therefore an important drug target. Little is known about the molecular mechanism of its activation by double-phosphorylation from MAP2Ks, due to the challenge of trapping a transient and dynamic...
ORGANISM(S): Homo sapiens (Human) 
2023-08-31 | PXD040499 | Pride
Kinases Hdx-ms Molecular dynamics Mapk Cryo-em Mkk6 
UnknownMKK6 controls T3-mediated browning of white adipose tissue.
Not available
S-EPMC5636784 | biostudies-literature
UnknownThe interaction of p38 with its upstream kinase MKK6.
Not available
S-EPMC7980501 | biostudies-literature
UnknownMKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2.
Not available
S-EPMC2856721 | biostudies-literature
UnknownDifferential roles of MAPK kinases MKK3 and MKK6 in osteoclastogenesis and bone loss.
Not available
S-EPMC3882259 | biostudies-literature
UnknownAnti‑oncogenic and pro‑myogenic action of the MKK6/p38/AKT axis induced by targeting MEK/ERK in embryonal rhabdomyosarcoma.
Not available
S-EPMC9350981 | biostudies-literature
UnknownBalance between MKK6 and MKK3 mediates p38 MAPK associated resistance to cisplatin in NSCLC.
Not available
S-EPMC3229586 | biostudies-literature
UnknownMonocytic cell differentiation from band-stage neutrophils under inflammatory conditions via MKK6 activation.
Not available
S-EPMC4536888 | biostudies-literature
UnknownHINKEL kinesin, ANP MAPKKKs and MKK6/ANQ MAPKK, which phosphorylates and activates MPK4 MAPK, constitute a pathway that is required for cytokinesis in Arabidopsis thaliana.
Not available
S-EPMC2951530 | biostudies-literature
UnknownConstitutive activation of MKK6 in chondrocytes of transgenic mice inhibits proliferation and delays endochondral bone formation.
Not available
S-EPMC1326166 | biostudies-literature
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