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TranscriptomicsPleiotropic effects of metformin on inflammation, oxidative and dicarbonyl stress in transgenic spontaneously hypertensive rats expressing human C-reactive protein.
Inflammation, oxidative and dicarbonyl stress play important roles in the pathophysiology of type 2 diabetes. Metformin is the first-line drug of choice for the treatment of type 2 diabetes because it effectively suppresses gluconeogenesis in the liver, however, its “pleiotropic“ effects remain cont...
ORGANISM(S): Rattus norvegicus 
2016-07-03 | E-MTAB-3791 | biostudies-arrayexpress
TranscriptomicsFumaric acid esters can block pro-inflammatory actions of human CRP and ameliorate metabolic disturbances in transgenic spontaneously hypertensive rats
Inflammation and oxidative stress have been implicated in the pathogenesis of metabolic disturbances. Esters of fumaric acid, mainly dimethyl fumarate (DMF), exhibit immunomodulatory, anti-inflammatory, and anti-oxidative effects. In the current study, we tested the hypothesis that fumaric acid este...
ORGANISM(S): Rattus norvegicus 
2015-12-31 | E-MTAB-2406 | biostudies-arrayexpress
TranscriptomicsDownregulation of Plzf gene ameliorates metabolic and cardiac traits in the spontaneously hypertensive rat.
The spontaneously hypertensive rat (SHR) is the most widely used model of essential hypertension and is predisposed to left ventricular hypertrophy, myocardial fibrosis, and metabolic disturbances. Recently, a quantitative trait locus (QTL) influencing blood pressure, left ventricular mass and heart...
ORGANISM(S): Rattus norvegicus 
2016-07-03 | E-MTAB-3831 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of Sprague Dawley Rat Skin Treated with Aldosterone or Vehicle on High-Salt Diet for 2 or 14 Days
This study investigates the molecular mechanisms underlying salt-sensitive hypertension in a model of primary aldosteronism using RNA-Seq analysis of Sprague Dawley rat skin. Unilaterally nephrectomized rats were treated with aldosterone or vehicle and fed a high-salt or low-salt diet. Tissue electr...
ORGANISM(S): Rattus norvegicus 
2026-01-20 | E-MTAB-14749 | biostudies-arrayexpress
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