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TranscriptomicsMLX transcriptional regulation in muscle cells
This study set out to identify MLX transcriptional targets in muscle cells. C2C12 Myoblasts were virally transduced to increase MLX activity, by overexpression of the wild-type protein; and to decrease MLX activity by overexpression of a dominant negative MLX protein and by shRNA induced knockdown o...
ORGANISM(S): Mus musculus 
2016-01-04 | E-GEOD-70028 | biostudies-arrayexpress
GenomicsThe glucose-sensing transcription factor MLX promotes myogenesis via myokine signaling
Metabolic stress and changes in nutrient levels modulate many aspects of skeletal muscle function during aging and disease. Growth factors and cytokines secreted by skeletal muscle, known as myokines, are important signaling factors but it is largely unknown whether they modulate muscle growth and d...
ORGANISM(S): Mus musculus 
2015-11-11 | E-GEOD-74678 | biostudies-arrayexpress
GenomicsTranscriptional and genomic occupancy profiling from MLX WT and MLX knockout mouse tissues.
Transcriptional and genomic occupancy profiling from MLX WT and MLX knockout mouse tissues.
PRJNA697964 | ENA
ProteomicsMLX phosphorylation is an evolutionarily conserved mechanism to promote lipid storage and sugar tolerance
To cope with food scarcity, animals store energy as lipids, which are produced from carbohydrates via de novo lipogenesis (DNL). The carbohydrate-responsive ChREBP-MLX complex is a master transcriptional regulator for DNL and lipid storage. However, our understanding of molecular mechanisms, particu...
ORGANISM(S): Homo sapiens (Human) 
2025-03-13 | PXD054667 | Pride
Carbohydrate and lipid metabolism Sugar tolerance Fly development 
GenomicsMLX siRNA knockdown in primary human hepatocytes
MLX siRNA knockdown in primary human hepatocytes
PRJNA907289 | ENA
GenomicsThe Myc-Like Mlx Network Impacts Aging and Metabolism
The Myc-Like Mlx Network Impacts Aging and Metabolism
PRJNA1041729 | ENA
TranscriptomicsTranscriptional and genomic occupancy profiling from MLX WT and MLX knockout mouse tissues.
We generated mice null for MAX-like Protein X (MLX), encoded by Mlx. All male mice are sterile. We profiled testes tissue from WT versus KO mice by RNA-Seq. We performed ChIP-Seq on WT and KO testes for MLX and MAX, as well as ChIP-Seq for MLX and MAX from primary B220+ splenic B cells, and ChIP-Seq...
ORGANISM(S): Mus musculus 
2021-07-31 | GSE165820 | GEO
TranscriptomicsMLX transcriptional regulation in muscle cells
This study set out to identify MLX transcriptional targets in muscle cells. C2C12 Myoblasts were virally transduced to increase MLX activity, by overexpression of the wild-type protein; and to decrease MLX activity by overexpression of a dominant negative MLX protein and by shRNA induced knockdown o...
ORGANISM(S): Mus musculus 
2016-01-04 | GSE70028 | GEO
GenomicsSuper-enhancer-driven MLX mediates redox balance maintanance via SLC7A11 in osteosarcoma
Super-enhancer-driven MLX mediates redox balance maintanance via SLC7A11 in osteosarcoma
PRJNA909175 | ENA
UnknownMLX phosphorylation stabilizes the ChREBP-MLX heterotetramer on tandem E-boxes to control carbohydrate and lipid metabolism.
Not available
S-EPMC11398402 | biostudies-literature
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