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MetabolomicsElevated brain manganese induces motor disease by upregulating the kynurenine pathway of tryptophan metabolism
Elevated brain levels of the essential metals manganese (Mn), copper, or iron induce motor disease. However, mechanisms of metal-induced motor disease are unclear and treatments are lacking. Elucidating the mechanisms of Mn-induced motor disease is particularly important because occupational and env...
2025-03-31 | MTBLS975 | MetaboLights
TranscriptomicsDifferential transcription of Geobacter sulfurreducens cells growing with Mn(IV) oxide or Fe(III) citrate provided as electron acceptor [Mn]
Whole-genome DNA microarray analysis of Geobacter sulfurreducens cells grown on Fe(III)-oxide or Mn(IV)-oxide versus cells grown on soluble Fe(III) citrate indicated that there were significant differences in transcription patterns during growth on the insoluble metal oxides compared to growth on so...
ORGANISM(S): Geobacter sulfurreducens 
2012-12-15 | E-GEOD-42919 | biostudies-arrayexpress
TranscriptomicsNext generation RNA sequencing to identify overexpressed transporter genes in Zymoseptoria tritici field strains
Septoria leaf blotch is a worldwide threat for wheat and mainly controlled by the application of synthetic fungicides. The fungal pathogen responsible for this disease, Zymoseptoria tritici, was shown as highly adaptable to its host plant, but also to fungicide challenge. Over the past decades it de...
ORGANISM(S): Zymoseptoria tritici 
2015-06-10 | E-GEOD-58672 | biostudies-arrayexpress
TranscriptomicsLoss of SLC30A10 manganese transporter alters expression of neurotransmission genes and activates hypoxia-inducible factor signaling in mice
The essential metal manganese (Mn) induces neuromotor disease at elevated levels. The manganese efflux transporter SLC30A10 regulates brain Mn levels. Homozygous loss-of-function mutations in SLC30A10 induce hereditary Mn neurotoxicity in humans. Our prior characterization of Slc30a10 knockout mice ...
ORGANISM(S): Mus musculus 
2024-02-09 | GSE247882 | GEO
ProteomicsConserved function of UPF0016 manganese transporter across human, plant and bacteria
The Uncharacterized Protein Family 0016 (UPF0016) is conserved throughout evolution. In humans, the member TMEM165 is a putative Golgi localized Ca2+ and/or Mn2+ transporter. Genes encoding UPF0016 proteins are also present in many bacteria, including the cyanobacteria Synechocystis (MNX/SynPAM71), ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2021-04-20 | PXD022763 | Pride
Mn transporter Arabidopsis Thylakoid Impactii Chloroplast Upf0016 
UnknownA Mn-sensing riboswitch activates expression of a Mn2+/Ca2+ ATPase transporter in Streptococcus.
Not available
S-EPMC6649816 | biostudies-literature
GenomicsLoss of SLC30A10 manganese transporter alters expression of neurotransmission genes and activates hypoxia-inducible factor signaling in mice
Loss of SLC30A10 manganese transporter alters expression of neurotransmission genes and activates hypoxia-inducible factor signaling in mice
PRJNA1040862 | ENA
UnknownA novel metal transporter mediating manganese export (MntX) regulates the Mn to Fe intracellular ratio and Neisseria meningitidis virulence.
Not available
S-EPMC3182930 | biostudies-literature
UnknownOsMTP11 is localised at the Golgi and contributes to Mn tolerance.
Not available
S-EPMC5681648 | biostudies-literature
UnknownEngineering an effective Mn-binding MRI reporter protein by subcellular targeting.
Not available
S-EPMC4470876 | biostudies-literature
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