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ProteomicsTranscriptomic and proteomic analysis of osteogenesis imperfecta disease-specific induced pluripotent stem cells
Background: Osteogenesis imperfecta (OI) is a rare genetic bone disease that causes bone fragility and growth deformities. OI-derived disease-specific induced pluripotent stem cells (iPSC) can reflect disease pathogenesis. Hence, investigating the pathogenesis of OI through OI-iPSCs holds significan...
ORGANISM(S): Homo Sapiens 
PXD065237 |
ProteomicsLC-MS/MS-based 4D Label-Free Proteomics Analysis of Bone Marrow Cells from ADO2 Mice
This project focuses on the global proteomic profiling of bone marrow cells (BMCs) in the ADO2 mouse model using LC-MS/MS-based 4D Label-Free Proteomics Analysis. The study aims to identify differentially expressed proteins and elucidate potential molecular mechanisms underlying osteopetrosis pathog...
ORGANISM(S): Rattus Rattus 
2025-02-05 | PXD060536 |
ProteomicsLC-MS/MS-based 4D Label-Free N-Glycosylation Proteomics Analysis of Bone Marrow Cells from ADO2 Mouse
This project aims to investigate N-linked glycosylation modifications in bone marrow cells (BMCs) of an autosomal dominant osteopetrosis type 2 (ADO2) mouse model carrying the Clcn7 (r284w) mutation. Using LC-MS/MS-based 4D Label-Free N-Glycosylation Proteomics Analysis, we identified significant al...
ORGANISM(S): Mus Musculus 
2025-02-05 | PXD060501 |
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