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TranscriptomicsAutotaxin and its product lysophosphatidic acid suppress brown adipose differentiation and promote diet-induced obesity in mice
Brown adipose tissue (BAT) is a thermogenic organ that dissipates stored energy as heat to maintain body temperature in infants and small mammals. This process may also provide protection from development of diet-induced obesity. We found that the bioactive lipid mediator lysophosphatidic acid (LP...
ORGANISM(S): Mus musculus 
2011-06-01 | E-GEOD-26442 | biostudies-arrayexpress
TranscriptomicsGene expression analysis at the intersection of ploidy and hybridity in maize.
Heterosis and polyploidy are two important aspects of plant evolution. To examine these issues, we conducted a global gene expression study of a maize ploidy series as well as a set of tetraploid inbred and hybrid lines. This gene expression analysis complements an earlier phenotypic study of these ...
ORGANISM(S): Zea mays 
2010-11-30 | E-GEOD-25526 | biostudies-arrayexpress
ProteomicsMultifunctional polyphenol-based silk hydrogel alleviates oxidative stress and enhances endogenous regeneration of osteochondral defects
The native microenvironment following osteochondral defect is not permissive for its endogenous regeneration. A variety of hydrogels have been developed to regulate cell behaviors; however, there is still a lack of hydrogels with multifunctional properties that can provide a supportive microenvironm...
ORGANISM(S): Rattus Rattus 
2021-11-28 | PXD030026 |
ProteomicsSilk-based hydrogel incorporated with metal-organic framework nanozymes for enhanced osteochondral regeneration
Osteochondral defects (OCD) cannot be efficiently repaired due to the unique physical architecture and the pathological microenvironment including enhanced oxidative stress and inflammation. Conventional strategies, such as the control of implant microstructure or the introduction of growth factors,...
ORGANISM(S): Rattus Norvegicus Mus Musculus 
2022-03-04 | PXD031852 |
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