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ProteomicsDifferential patterns of protein expression in monolayer or spheroid melanoma cell models of acquired resistance to BRAF and MEK1/2 inhibitors
Mitogen activated protein kinase (MAPK) inhibitors are important therapies for treating many cancers. However, the development of acquired resistance to most protein kinase inhibitors limit their ability to provide durable responses. Approximately 50% of malignant melanomas contain activating mutati...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD026952 | Pride
Monolayer Braf Drug resistance Protein kinases Kinase targeted therapy Selumetinib Spheroids Melanoma Vemurafenib Extracellular-signal regulated kinases 
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