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TranscriptomicsConcordance of deregulated mechanisms unveiled in underpowered experiments: PTBP1 knockdown case study
Background: Genome-wide transcriptome profiling generated by microarray and RNA-Seq often provides deregulated genes or pathways applicable only to larger cohort. On the other hand, individualized interpretation of transcriptomes is increasely pursued to improve diagnosis, prognosis, and patient tre...
ORGANISM(S): Homo sapiens 
2013-11-20 | E-GEOD-52493 | biostudies-arrayexpress
MetabolomicsAn ancient residue metabolomics-based method to distinguish use of closely related plant species in ancient pipes

Residues from ancient artifacts can help identify which plant species were used for their psychoactive properties, providing important information regarding the deep-time co-evolutionary relationship between plants and humans. However, relying on the presence or absence of one or several biomarke...

2020-07-21 | MTBLS890 | MetaboLights
UnknownPhenotyping, Etiological Factors, and Biomarkers: Toward Precision Medicine in Autism Spectrum Disorders.
Not available
S-EPMC5102276 | biostudies-literature
UnknownBerry skin development in Norton grape: distinct patterns of transcriptional regulation and flavonoid biosynthesis.
Not available
S-EPMC3025947 | biostudies-literature
UnknownSystemic influences contribute to prolonged microvascular rarefaction after brain irradiation: a role for endothelial progenitor cells.
Not available
S-EPMC4166745 | biostudies-literature
TranscriptomicsTranscription profiling of rat model of aging - progressive aortic vasculopathy
This study utilized a standard rat model of aging and global gene expression analyses to attempt to identify the most appropriate time points to study vascular aging and to identify molecules associated with the development of pathology. Recent studies have established that age is the major risk fac...
ORGANISM(S): Rattus norvegicus 
2008-06-15 | E-GEOD-7281 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human normal melanocytes and melamoma cell lines reveal defective cell cycle checkpoint functions in melanoma are associated with altered patterns of gene expression
Defects in DNA damage responses may underlie genetic instability and malignant progression in melanoma. Cultures of normal human melanocytes (NHMs) and melanoma lines were analyzed to determine whether global patterns of gene expression could predict the efficacy of DNA damage cell cycle checkpoints...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7469 | biostudies-arrayexpress
UnknownHurricanes fertilize mangrove forests in the Gulf of Mexico (Florida Everglades, USA).
Not available
S-EPMC7060680 | biostudies-literature
UnknownClinical and Genetic Risk Factors for Acute Pancreatitis in Patients With Acute Lymphoblastic Leukemia.
Not available
S-EPMC4962704 | biostudies-literature
TranscriptomicsGenomic Analysis Reveals Distinct Mechanisms and Functional Classes of SOX10-Regulated Genes in Melanocytes [gene expression]
We performed ChIP-Seq analysis of SOX10, histone H3 lysine 27 acetylation (H3K27ac) and H3K27 trimethylation (H3K27me3) in melanocytes to profile the genomic binding sites of SOX10 and the chromatin landscape. In parallel, we generated Sox10 haploinsufficient cell lines using gene knockout approache...
ORGANISM(S): Mus musculus 
2015-07-03 | E-GEOD-69860 | biostudies-arrayexpress
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